Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. / Haaser, Miriam; Naelapaa, Kaisa; Gordon, Keith C; Pepper, Michael; Rantanen, Jukka; Strachan, Clare J; Taday, Philip F; Zeitler, J Axel; Rades, Thomas.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 3 Pt B, 11.2013, p. 1095-102.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
AU - Haaser, Miriam
AU - Naelapaa, Kaisa
AU - Gordon, Keith C
AU - Pepper, Michael
AU - Rantanen, Jukka
AU - Strachan, Clare J
AU - Taday, Philip F
AU - Zeitler, J Axel
AU - Rades, Thomas
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p
AB - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p
U2 - 10.1016/j.ejpb.2013.03.019
DO - 10.1016/j.ejpb.2013.03.019
M3 - Journal article
C2 - 23563103
VL - 85
SP - 1095
EP - 1102
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
IS - 3 Pt B
ER -
ID: 104835134