Estimating Renal Function Following Lung Transplantation
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Fulltext
Final published version, 278 KB, PDF document
Background: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. However, no prospective longitudinal studies directly comparing the performance of equations for estimating GFR in this patient population currently exist. Methods: In total, 32 patients undergoing LTx met the study criteria. At pre-LTx and 1-, 3-, and 12-weeks post-LTx, GFR was determined by51 Cr-EDTA and by equations for estimating GFR based on plasma (P)-Creatinine, P-Cystatin C, or a combination of both. Results: Measured GFR declined from 98.0 mL/min/1.73 m2 at pre-LTx to 54.1 mL/min/1.73 m2 at 12-weeks post-LTx. Equations based on P-Creatinine underestimated GFR decline after LTx, whereas equations based on P-Cystatin C overestimated this decline. Overall, the 2021 CKD-EPI combination equation had the lowest bias and highest precision at both pre-LTx and post-LTx. Conclusions: Caution must be applied when interpreting renal function based on equations for estimating GFR in the acute postoperative period following LTx. Simplified methods for measuring GFR may allow for more widespread use of measured GFR in this vulnerable patient population.
Original language | English |
---|---|
Article number | 1496 |
Journal | Journal of Clinical Medicine |
Volume | 11 |
Issue number | 6 |
Number of pages | 13 |
ISSN | 2077-0383 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Funding Information:
Funding: M.H. was supported by an unrestricted grant from the Helen and Ejnar Bjørnow Foundation and a grant from the Lundbeck Foundation (R187-2015-2148). M.B.H. was supported by a postdoctoral fellowship from The Capital Region’s Research Foundation for Health Research, Denmark (A6882).
Funding Information:
M.H. was supported by an unrestricted grant from the Helen and Ejnar Bj?rnow Foundation and a grant from the Lundbeck Foundation (R187-2015-2148). M.B.H. was supported by a postdoctoral fellowship from The Capital Region?s Research Foundation for Health Research, Denmark (A6882).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- Cystatin c, Estimated glomerular filtration rate, Immunosuppression, Lung transplantation, Measured glomerular filtration rate
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 302347166