Elicitation threshold of cobalt chloride: analysis of patch test dose-response studies
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Elicitation threshold of cobalt chloride : analysis of patch test dose-response studies. / Fischer, Louise A; Johansen, Jeanne D; Voelund, Aage; Lidén, Carola; Julander, Anneli; Midander, Klara; Menné, Torkil; Thyssen, Jacob P.
In: Contact Dermatitis, Vol. 74, No. 2, 02.2016, p. 105-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Elicitation threshold of cobalt chloride
T2 - analysis of patch test dose-response studies
AU - Fischer, Louise A
AU - Johansen, Jeanne D
AU - Voelund, Aage
AU - Lidén, Carola
AU - Julander, Anneli
AU - Midander, Klara
AU - Menné, Torkil
AU - Thyssen, Jacob P
N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/2
Y1 - 2016/2
N2 - BACKGROUND: Cobalt is a strong skin sensitizer (grade 5 of 5 in the guinea-pig maximization test) that is used in various industrial and consumer applications. To prevent sensitization to cobalt and elicitation of allergic cobalt dermatitis, information about the elicitation threshold level of cobalt is important.OBJECTIVE: To identify the dermatitis elicitation threshold levels in cobalt-allergic individuals.MATERIALS AND METHODS: Published patch test dose-response studies were reviewed to determine the elicitation dose (ED) levels in dermatitis patients with a previous positive patch test reaction to cobalt. A logistic dose-response model was applied to data collected from the published literature to estimate ED values. The 95% confidence interval (CI) for the ratio of mean doses that can elicit a reaction in 10% (ED(10)) of a population was calculated with Fieller's method.RESULTS: On the basis of five included studies, the ED10 values of aqueous cobalt chloride ranged between 0.0663 and 1.95 µg cobalt/cm(2), corresponding to 30.8-259 ppm.CONCLUSIONS: Our analysis provides an overview of the doses of cobalt that are required to elicit allergic cobalt contactdermatitis in sensitized individuals, and thereby the basis for future prevention of cobalt allergy.
AB - BACKGROUND: Cobalt is a strong skin sensitizer (grade 5 of 5 in the guinea-pig maximization test) that is used in various industrial and consumer applications. To prevent sensitization to cobalt and elicitation of allergic cobalt dermatitis, information about the elicitation threshold level of cobalt is important.OBJECTIVE: To identify the dermatitis elicitation threshold levels in cobalt-allergic individuals.MATERIALS AND METHODS: Published patch test dose-response studies were reviewed to determine the elicitation dose (ED) levels in dermatitis patients with a previous positive patch test reaction to cobalt. A logistic dose-response model was applied to data collected from the published literature to estimate ED values. The 95% confidence interval (CI) for the ratio of mean doses that can elicit a reaction in 10% (ED(10)) of a population was calculated with Fieller's method.RESULTS: On the basis of five included studies, the ED10 values of aqueous cobalt chloride ranged between 0.0663 and 1.95 µg cobalt/cm(2), corresponding to 30.8-259 ppm.CONCLUSIONS: Our analysis provides an overview of the doses of cobalt that are required to elicit allergic cobalt contactdermatitis in sensitized individuals, and thereby the basis for future prevention of cobalt allergy.
KW - Journal Article
U2 - 10.1111/cod.12499
DO - 10.1111/cod.12499
M3 - Journal article
C2 - 26563947
VL - 74
SP - 105
EP - 109
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 2
ER -
ID: 164465506