Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death: Results From the Copenhagen ECG Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death : Results From the Copenhagen ECG Study. / Rasmussen, Peter Vibe; Nielsen, Jonas Bille; Pietersen, Adrian; Graff, Claus; Lind, Bent; Struijk, Johannes Jan; Olesen, Morten Salling; Haunsø, Stig; Køber, Lars; Svendsen, Jesper Hastrup; Holst, Anders Gaarsdal.

In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 3, No. 3, e000549, 06.2014, p. 1-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rasmussen, PV, Nielsen, JB, Pietersen, A, Graff, C, Lind, B, Struijk, JJ, Olesen, MS, Haunsø, S, Køber, L, Svendsen, JH & Holst, AG 2014, 'Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death: Results From the Copenhagen ECG Study', American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, vol. 3, no. 3, e000549, pp. 1-16. https://doi.org/10.1161/JAHA.113.000549

APA

Rasmussen, P. V., Nielsen, J. B., Pietersen, A., Graff, C., Lind, B., Struijk, J. J., Olesen, M. S., Haunsø, S., Køber, L., Svendsen, J. H., & Holst, A. G. (2014). Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death: Results From the Copenhagen ECG Study. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, 3(3), 1-16. [e000549]. https://doi.org/10.1161/JAHA.113.000549

Vancouver

Rasmussen PV, Nielsen JB, Pietersen A, Graff C, Lind B, Struijk JJ et al. Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death: Results From the Copenhagen ECG Study. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2014 Jun;3(3):1-16. e000549. https://doi.org/10.1161/JAHA.113.000549

Author

Rasmussen, Peter Vibe ; Nielsen, Jonas Bille ; Pietersen, Adrian ; Graff, Claus ; Lind, Bent ; Struijk, Johannes Jan ; Olesen, Morten Salling ; Haunsø, Stig ; Køber, Lars ; Svendsen, Jesper Hastrup ; Holst, Anders Gaarsdal. / Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death : Results From the Copenhagen ECG Study. In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2014 ; Vol. 3, No. 3. pp. 1-16.

Bibtex

@article{bf2774dd68284e30b80c9bd28910df3c,
title = "Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death: Results From the Copenhagen ECG Study",
abstract = "BACKGROUND: We sought to perform a study assessing the association between electrocardiographic ST-segment deviations and cardiovascular death (CVD), in relation to sex and age (≥ and <65 years), in a large primary care population without overt ischemic heart disease.METHODS AND RESULTS: Using computerized analysis of ECGs from 285 194 persons, we evaluated the association between precordial ST-segment deviations and the risk of CVD. All data on medication, comorbidity, and outcomes were retrieved from Danish registries. After a median follow-up period of 5.8 years, there were 6679 cardiovascular deaths. Increasing ST-depression was associated with an increased risk of CVD in almost all of the precordial leads, with the most robust association seen in lead V5 to V6. ST-elevations in lead V2 to V6 were associated with increased risk of CVD in young women, but not in men. However, ST-elevations in V1 increased the risk for both genders and age groups, exemplified by a HR of 1.80 (95% CI [1.19 to 2.74], P=0.005) for men <65 years with ST-elevations ≥ 150 μV versus a nondeviating ST-segment (-50 μV to +50 μV). In contrast, for men <65 years, ST-elevations in lead V2 to V3 conferred a decreased risk of CVD with a HR of 0.77 (95% CI [0.62 to 0.96], P<0.001) for ST-elevations ≥ 150 μV in V2.CONCLUSION: We found that ST-depressions were associated with a dose-responsive increased risk of CVD in nearly all the precordial leads. ST-elevations conferred an increased risk of CVD in women and with regard to lead V1 also in men. However, ST-elevations in V2 to V3 were associated with a decreased risk of CVD in young men.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Denmark, Electrocardiography, Female, Heart, Humans, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Sex Factors",
author = "Rasmussen, {Peter Vibe} and Nielsen, {Jonas Bille} and Adrian Pietersen and Claus Graff and Bent Lind and Struijk, {Johannes Jan} and Olesen, {Morten Salling} and Stig Hauns{\o} and Lars K{\o}ber and Svendsen, {Jesper Hastrup} and Holst, {Anders Gaarsdal}",
year = "2014",
month = jun,
doi = "10.1161/JAHA.113.000549",
language = "English",
volume = "3",
pages = "1--16",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Electrocardiographic Precordial ST‐Segment Deviations and the Risk of Cardiovascular Death

T2 - Results From the Copenhagen ECG Study

AU - Rasmussen, Peter Vibe

AU - Nielsen, Jonas Bille

AU - Pietersen, Adrian

AU - Graff, Claus

AU - Lind, Bent

AU - Struijk, Johannes Jan

AU - Olesen, Morten Salling

AU - Haunsø, Stig

AU - Køber, Lars

AU - Svendsen, Jesper Hastrup

AU - Holst, Anders Gaarsdal

PY - 2014/6

Y1 - 2014/6

N2 - BACKGROUND: We sought to perform a study assessing the association between electrocardiographic ST-segment deviations and cardiovascular death (CVD), in relation to sex and age (≥ and <65 years), in a large primary care population without overt ischemic heart disease.METHODS AND RESULTS: Using computerized analysis of ECGs from 285 194 persons, we evaluated the association between precordial ST-segment deviations and the risk of CVD. All data on medication, comorbidity, and outcomes were retrieved from Danish registries. After a median follow-up period of 5.8 years, there were 6679 cardiovascular deaths. Increasing ST-depression was associated with an increased risk of CVD in almost all of the precordial leads, with the most robust association seen in lead V5 to V6. ST-elevations in lead V2 to V6 were associated with increased risk of CVD in young women, but not in men. However, ST-elevations in V1 increased the risk for both genders and age groups, exemplified by a HR of 1.80 (95% CI [1.19 to 2.74], P=0.005) for men <65 years with ST-elevations ≥ 150 μV versus a nondeviating ST-segment (-50 μV to +50 μV). In contrast, for men <65 years, ST-elevations in lead V2 to V3 conferred a decreased risk of CVD with a HR of 0.77 (95% CI [0.62 to 0.96], P<0.001) for ST-elevations ≥ 150 μV in V2.CONCLUSION: We found that ST-depressions were associated with a dose-responsive increased risk of CVD in nearly all the precordial leads. ST-elevations conferred an increased risk of CVD in women and with regard to lead V1 also in men. However, ST-elevations in V2 to V3 were associated with a decreased risk of CVD in young men.

AB - BACKGROUND: We sought to perform a study assessing the association between electrocardiographic ST-segment deviations and cardiovascular death (CVD), in relation to sex and age (≥ and <65 years), in a large primary care population without overt ischemic heart disease.METHODS AND RESULTS: Using computerized analysis of ECGs from 285 194 persons, we evaluated the association between precordial ST-segment deviations and the risk of CVD. All data on medication, comorbidity, and outcomes were retrieved from Danish registries. After a median follow-up period of 5.8 years, there were 6679 cardiovascular deaths. Increasing ST-depression was associated with an increased risk of CVD in almost all of the precordial leads, with the most robust association seen in lead V5 to V6. ST-elevations in lead V2 to V6 were associated with increased risk of CVD in young women, but not in men. However, ST-elevations in V1 increased the risk for both genders and age groups, exemplified by a HR of 1.80 (95% CI [1.19 to 2.74], P=0.005) for men <65 years with ST-elevations ≥ 150 μV versus a nondeviating ST-segment (-50 μV to +50 μV). In contrast, for men <65 years, ST-elevations in lead V2 to V3 conferred a decreased risk of CVD with a HR of 0.77 (95% CI [0.62 to 0.96], P<0.001) for ST-elevations ≥ 150 μV in V2.CONCLUSION: We found that ST-depressions were associated with a dose-responsive increased risk of CVD in nearly all the precordial leads. ST-elevations conferred an increased risk of CVD in women and with regard to lead V1 also in men. However, ST-elevations in V2 to V3 were associated with a decreased risk of CVD in young men.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Cardiovascular Diseases

KW - Denmark

KW - Electrocardiography

KW - Female

KW - Heart

KW - Humans

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Risk Factors

KW - Sex Factors

U2 - 10.1161/JAHA.113.000549

DO - 10.1161/JAHA.113.000549

M3 - Journal article

C2 - 24815495

VL - 3

SP - 1

EP - 16

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 3

M1 - e000549

ER -

ID: 138384113