Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria

Research output: Contribution to journalJournal articleResearchpeer-review

  • F Abacassamo
  • S Enosse
  • J J Aponte
  • F X Gómez-Olivé
  • L Quintó
  • S Mabunda
  • A Barreto
  • Magnussen, Pascal
  • A M Rønn
  • R Thompson
  • P L Alonso
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomplicated malaria, of three combinations: AQ + SP, artesunate (AR) + SP and AQ + AR. Based on the WHO (1996, WHO/MAL/96.1077) in vivo protocol, we conducted two open, randomized, clinical trials. Children aged 6-59 months with axillary body temperature > or = 37.5 degrees C and non-complicated malaria were randomly allocated to treatment groups and followed up for 21 days (first and second trial) and 28 days (first trial). The therapeutic efficacy of AQ (91.6%) was better than that of SP (82.7%) and CQ (47.1%). After 14 days, 69% of the strains were parasitologically resistant to CQ, 21.4% to SP and 26% to AQ. Co-administration of AQ + SP, AR + SP and AQ + AR was safe and had 100% clinical efficacy at 14-day follow-up. The combination therapies affected rapid fever clearance time and reduced the incidence of gametocytaemia during follow-up.
Original languageEnglish
JournalTropical Medicine & International Health
Issue number2
Pages (from-to)200-8
Number of pages8
Publication statusPublished - 2004

Bibliographical note

Keywords: Amodiaquine; Animals; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Mozambique; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Treatment Outcome

ID: 17656847