Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk. / Thomsen, L L; Brennum, J; Iversen, Helle Klingenberg; Olesen, J.

In: Ugeskrift for Laeger, Vol. 159, No. 30, 21.07.1997, p. 4645-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thomsen, LL, Brennum, J, Iversen, HK & Olesen, J 1997, 'Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk', Ugeskrift for Laeger, vol. 159, no. 30, pp. 4645-8.

APA

Thomsen, L. L., Brennum, J., Iversen, H. K., & Olesen, J. (1997). Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk. Ugeskrift for Laeger, 159(30), 4645-8.

Vancouver

Thomsen LL, Brennum J, Iversen HK, Olesen J. Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk. Ugeskrift for Laeger. 1997 Jul 21;159(30):4645-8.

Author

Thomsen, L L ; Brennum, J ; Iversen, Helle Klingenberg ; Olesen, J. / Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk. In: Ugeskrift for Laeger. 1997 ; Vol. 159, No. 30. pp. 4645-8.

Bibtex

@article{1b7d2a1133a749d6ba82ec98af8c87c2,
title = "Effekten af nitrogenoxiddonoren glyceryltrinitrat p{\aa} humane smertetaerskler for tryk",
abstract = "The purpose of the present study was to examine the effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) on nociceptive thresholds in man. On two different study days twelve healthy subjects received a stair case infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min 20 min each dose) or placebo in a randomized double-blind cross-over design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection- and tolerance thresholds were determined by pressure algometry in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo the three higher GTN doses induced a decrease in both detection- and tolerance-thresholds in the temporal region with interposed myofascial tissue. No such changes were observed in the two other stimulated regions. These results could reflect central facilitation of nociception by NO. However, convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO may provide a more likely explanation.",
keywords = "Adult, Cross-Over Studies, Double-Blind Method, Female, Humans, Infusions, Intravenous, Male, Neurotransmitter Agents, Nitric Oxide, Nitroglycerin, Nociceptors, Pain Threshold, Pressure, Vasodilator Agents",
author = "Thomsen, {L L} and J Brennum and Iversen, {Helle Klingenberg} and J Olesen",
year = "1997",
month = jul,
day = "21",
language = "Dansk",
volume = "159",
pages = "4645--8",
journal = "Ugeskrift for Laeger",
issn = "0041-5782",
publisher = "Almindelige Danske Laegeforening",
number = "30",

}

RIS

TY - JOUR

T1 - Effekten af nitrogenoxiddonoren glyceryltrinitrat på humane smertetaerskler for tryk

AU - Thomsen, L L

AU - Brennum, J

AU - Iversen, Helle Klingenberg

AU - Olesen, J

PY - 1997/7/21

Y1 - 1997/7/21

N2 - The purpose of the present study was to examine the effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) on nociceptive thresholds in man. On two different study days twelve healthy subjects received a stair case infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min 20 min each dose) or placebo in a randomized double-blind cross-over design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection- and tolerance thresholds were determined by pressure algometry in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo the three higher GTN doses induced a decrease in both detection- and tolerance-thresholds in the temporal region with interposed myofascial tissue. No such changes were observed in the two other stimulated regions. These results could reflect central facilitation of nociception by NO. However, convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO may provide a more likely explanation.

AB - The purpose of the present study was to examine the effect of the nitric oxide (NO) donor glyceryl trinitrate (GTN) on nociceptive thresholds in man. On two different study days twelve healthy subjects received a stair case infusion of GTN (0.015, 0.25, 1.0, 2.0 micrograms/kg/min 20 min each dose) or placebo in a randomized double-blind cross-over design. Before the infusion and after 15 min of infusion on each dose, pressure pain detection- and tolerance thresholds were determined by pressure algometry in three different anatomic regions (finger, a temporal region with interposed myofascial tissue and a temporal region without interposed myofascial tissue). Relative to placebo the three higher GTN doses induced a decrease in both detection- and tolerance-thresholds in the temporal region with interposed myofascial tissue. No such changes were observed in the two other stimulated regions. These results could reflect central facilitation of nociception by NO. However, convergence of nociceptive input from pericranial myofascial tissue and from cephalic blood vessels dilated by NO may provide a more likely explanation.

KW - Adult

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Infusions, Intravenous

KW - Male

KW - Neurotransmitter Agents

KW - Nitric Oxide

KW - Nitroglycerin

KW - Nociceptors

KW - Pain Threshold

KW - Pressure

KW - Vasodilator Agents

M3 - Tidsskriftartikel

C2 - 9245041

VL - 159

SP - 4645

EP - 4648

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 30

ER -

ID: 128983893