Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome

Research output: Contribution to journalJournal articlepeer-review

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Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. / Gottschalck, Ida B; Jeppesen, Palle B; Hartmann, Bolette; Holst, Jens Juul; Henriksen, Dennis B.

In: Scandinavian Journal of Gastroenterology, Vol. 43, No. 11, 2008, p. 1304-10.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Gottschalck, IB, Jeppesen, PB, Hartmann, B, Holst, JJ & Henriksen, DB 2008, 'Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome', Scandinavian Journal of Gastroenterology, vol. 43, no. 11, pp. 1304-10. https://doi.org/10.1080/00365520802200028

APA

Gottschalck, I. B., Jeppesen, P. B., Hartmann, B., Holst, J. J., & Henriksen, D. B. (2008). Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. Scandinavian Journal of Gastroenterology, 43(11), 1304-10. https://doi.org/10.1080/00365520802200028

Vancouver

Gottschalck IB, Jeppesen PB, Hartmann B, Holst JJ, Henriksen DB. Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. Scandinavian Journal of Gastroenterology. 2008;43(11):1304-10. https://doi.org/10.1080/00365520802200028

Author

Gottschalck, Ida B ; Jeppesen, Palle B ; Hartmann, Bolette ; Holst, Jens Juul ; Henriksen, Dennis B. / Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. In: Scandinavian Journal of Gastroenterology. 2008 ; Vol. 43, No. 11. pp. 1304-10.

Bibtex

@article{e36c5037422049409daee37295f07d71,
title = "Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome",
abstract = "OBJECTIVE: The gut hormone GLP-2 (glucagon-like peptide-2) seems to be involved in the circadian pattern of bone resorption, whereas parathyroid hormone (PTH) is an established key hormone in bone turnover. Endogenous GLP-2 secretion is lacking in colectomized patients with short-bowel syndrome (SBS) and they have reduced bone mineral density (BMD). The aim of the study was to investigate the anti-resorptive effect (assessed by s-CTX) of 14 days of GLP-2 treatment in these patients and to determine whether 56 days of treatment would improve BMD. PTH secretion in response to GLP-2 was also investigated in colectomized SBS patients and colectomized controls (with ileostomy).MATERIAL AND METHODS: Eight SBS patients and 13 patients with ileostomy were treated with subcutaneous injections of 1600 microg GLP-2 at bedtime for 56 and 14 consecutive days, respectively. BMD was determined at days 1 and 56 in SBS patients. On days 1 and 14, measurements of CTX, P1NP and PTH were taken 4 h after the GLP-2 injection.RESULTS: Patients with ileostomy showed a significant reduction in bone resorption after GLP-2 injections at days 1 and 14. In contrast, there was no change in s-CTX after 1 and 14 days in the SBS patients, and after 56 days of GLP-2 treatment there was no improvement in BMD. A significant reduction in PTH secretion in response to GLP-2 was observed only in patients with ileostomy.CONCLUSIONS: The decreased bone resorption in response to GLP-2 injections cannot be elicited in SBS patients and therefore precludes treatment of their osteopenia with GLP-2. The anti-resorptive response to GLP-2 seems to require an intact small intestine and may involve suppression of PTH secretion.",
keywords = "Adult, Body Mass Index, Bone Density, Bone Density Conservation Agents, Bone Resorption, Circadian Rhythm, Colectomy, Female, Glucagon-Like Peptide 2, Humans, Ileostomy, Injections, Subcutaneous, Jejunostomy, Male, Middle Aged, Parathyroid Hormone, Short Bowel Syndrome, Treatment Outcome",
author = "Gottschalck, {Ida B} and Jeppesen, {Palle B} and Bolette Hartmann and Holst, {Jens Juul} and Henriksen, {Dennis B}",
year = "2008",
doi = "10.1080/00365520802200028",
language = "English",
volume = "43",
pages = "1304--10",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "11",

}

RIS

TY - JOUR

T1 - Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome

AU - Gottschalck, Ida B

AU - Jeppesen, Palle B

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Henriksen, Dennis B

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The gut hormone GLP-2 (glucagon-like peptide-2) seems to be involved in the circadian pattern of bone resorption, whereas parathyroid hormone (PTH) is an established key hormone in bone turnover. Endogenous GLP-2 secretion is lacking in colectomized patients with short-bowel syndrome (SBS) and they have reduced bone mineral density (BMD). The aim of the study was to investigate the anti-resorptive effect (assessed by s-CTX) of 14 days of GLP-2 treatment in these patients and to determine whether 56 days of treatment would improve BMD. PTH secretion in response to GLP-2 was also investigated in colectomized SBS patients and colectomized controls (with ileostomy).MATERIAL AND METHODS: Eight SBS patients and 13 patients with ileostomy were treated with subcutaneous injections of 1600 microg GLP-2 at bedtime for 56 and 14 consecutive days, respectively. BMD was determined at days 1 and 56 in SBS patients. On days 1 and 14, measurements of CTX, P1NP and PTH were taken 4 h after the GLP-2 injection.RESULTS: Patients with ileostomy showed a significant reduction in bone resorption after GLP-2 injections at days 1 and 14. In contrast, there was no change in s-CTX after 1 and 14 days in the SBS patients, and after 56 days of GLP-2 treatment there was no improvement in BMD. A significant reduction in PTH secretion in response to GLP-2 was observed only in patients with ileostomy.CONCLUSIONS: The decreased bone resorption in response to GLP-2 injections cannot be elicited in SBS patients and therefore precludes treatment of their osteopenia with GLP-2. The anti-resorptive response to GLP-2 seems to require an intact small intestine and may involve suppression of PTH secretion.

AB - OBJECTIVE: The gut hormone GLP-2 (glucagon-like peptide-2) seems to be involved in the circadian pattern of bone resorption, whereas parathyroid hormone (PTH) is an established key hormone in bone turnover. Endogenous GLP-2 secretion is lacking in colectomized patients with short-bowel syndrome (SBS) and they have reduced bone mineral density (BMD). The aim of the study was to investigate the anti-resorptive effect (assessed by s-CTX) of 14 days of GLP-2 treatment in these patients and to determine whether 56 days of treatment would improve BMD. PTH secretion in response to GLP-2 was also investigated in colectomized SBS patients and colectomized controls (with ileostomy).MATERIAL AND METHODS: Eight SBS patients and 13 patients with ileostomy were treated with subcutaneous injections of 1600 microg GLP-2 at bedtime for 56 and 14 consecutive days, respectively. BMD was determined at days 1 and 56 in SBS patients. On days 1 and 14, measurements of CTX, P1NP and PTH were taken 4 h after the GLP-2 injection.RESULTS: Patients with ileostomy showed a significant reduction in bone resorption after GLP-2 injections at days 1 and 14. In contrast, there was no change in s-CTX after 1 and 14 days in the SBS patients, and after 56 days of GLP-2 treatment there was no improvement in BMD. A significant reduction in PTH secretion in response to GLP-2 was observed only in patients with ileostomy.CONCLUSIONS: The decreased bone resorption in response to GLP-2 injections cannot be elicited in SBS patients and therefore precludes treatment of their osteopenia with GLP-2. The anti-resorptive response to GLP-2 seems to require an intact small intestine and may involve suppression of PTH secretion.

KW - Adult

KW - Body Mass Index

KW - Bone Density

KW - Bone Density Conservation Agents

KW - Bone Resorption

KW - Circadian Rhythm

KW - Colectomy

KW - Female

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Ileostomy

KW - Injections, Subcutaneous

KW - Jejunostomy

KW - Male

KW - Middle Aged

KW - Parathyroid Hormone

KW - Short Bowel Syndrome

KW - Treatment Outcome

U2 - 10.1080/00365520802200028

DO - 10.1080/00365520802200028

M3 - Journal article

C2 - 18609184

VL - 43

SP - 1304

EP - 1310

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 11

ER -

ID: 132048884