Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial. / Egefjord, Lærke; Gejl, Michael; Møller, Peter Arne; Brændgaard, Hans; Gottrup, Hanne; Antropova, Olga; Møller, Niels; Poulsen, Henrik E; Gjedde, Albert; Brock, Birgitte; Rungby, Jørgen.

In: Danish Medical Bulletin (Online), Vol. 59, No. 10, 10.2012, p. A4519.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Egefjord, L, Gejl, M, Møller, PA, Brændgaard, H, Gottrup, H, Antropova, O, Møller, N, Poulsen, HE, Gjedde, A, Brock, B & Rungby, J 2012, 'Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial', Danish Medical Bulletin (Online), vol. 59, no. 10, pp. A4519. <http://www.danmedj.dk/portal/pls/portal/!PORTAL.wwpob_page.show?_docname=9286990.PDF>

APA

Egefjord, L., Gejl, M., Møller, P. A., Brændgaard, H., Gottrup, H., Antropova, O., Møller, N., Poulsen, H. E., Gjedde, A., Brock, B., & Rungby, J. (2012). Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial. Danish Medical Bulletin (Online), 59(10), A4519. http://www.danmedj.dk/portal/pls/portal/!PORTAL.wwpob_page.show?_docname=9286990.PDF

Vancouver

Egefjord L, Gejl M, Møller PA, Brændgaard H, Gottrup H, Antropova O et al. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial. Danish Medical Bulletin (Online). 2012 Oct;59(10):A4519.

Author

Egefjord, Lærke ; Gejl, Michael ; Møller, Peter Arne ; Brændgaard, Hans ; Gottrup, Hanne ; Antropova, Olga ; Møller, Niels ; Poulsen, Henrik E ; Gjedde, Albert ; Brock, Birgitte ; Rungby, Jørgen. / Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial. In: Danish Medical Bulletin (Online). 2012 ; Vol. 59, No. 10. pp. A4519.

Bibtex

@article{a7b3a2a21320492594e85a03b35a87f6,
title = "Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial",
abstract = "Type 2 diabetes (DM-2) increases the risk of developing Alzheimer´s disease (AD), and patients with AD are more likely to develop DM-2. DM-2 and AD share some pathophysiological features. In AD, amyloid-{\ss} (A{\ss}) is accumulated as extracellular plaques in the gray matter of the brain, while in DM-2 islet amyloid polypeptide (IAPP) is accumulated in the pancreas. Premature cellular degeneration is seen in both diseases. Glucagon-like peptide-1 (GLP-1) reduces the amount of A{\ss} and improves cognition in animal studies. The present study tests the hypothesis that treatment with the long-acting GLP-1 receptor agonist liraglutide affects the accumulation of A{\ss} in patients with AD.",
author = "L{\ae}rke Egefjord and Michael Gejl and M{\o}ller, {Peter Arne} and Hans Br{\ae}ndgaard and Hanne Gottrup and Olga Antropova and Niels M{\o}ller and Poulsen, {Henrik E} and Albert Gjedde and Birgitte Brock and J{\o}rgen Rungby",
year = "2012",
month = oct,
language = "English",
volume = "59",
pages = "A4519",
journal = "Danish Medical Journal",
issn = "2245-1919",
publisher = "Almindelige Danske Laegeforening",
number = "10",

}

RIS

TY - JOUR

T1 - Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial

AU - Egefjord, Lærke

AU - Gejl, Michael

AU - Møller, Peter Arne

AU - Brændgaard, Hans

AU - Gottrup, Hanne

AU - Antropova, Olga

AU - Møller, Niels

AU - Poulsen, Henrik E

AU - Gjedde, Albert

AU - Brock, Birgitte

AU - Rungby, Jørgen

PY - 2012/10

Y1 - 2012/10

N2 - Type 2 diabetes (DM-2) increases the risk of developing Alzheimer´s disease (AD), and patients with AD are more likely to develop DM-2. DM-2 and AD share some pathophysiological features. In AD, amyloid-ß (Aß) is accumulated as extracellular plaques in the gray matter of the brain, while in DM-2 islet amyloid polypeptide (IAPP) is accumulated in the pancreas. Premature cellular degeneration is seen in both diseases. Glucagon-like peptide-1 (GLP-1) reduces the amount of Aß and improves cognition in animal studies. The present study tests the hypothesis that treatment with the long-acting GLP-1 receptor agonist liraglutide affects the accumulation of Aß in patients with AD.

AB - Type 2 diabetes (DM-2) increases the risk of developing Alzheimer´s disease (AD), and patients with AD are more likely to develop DM-2. DM-2 and AD share some pathophysiological features. In AD, amyloid-ß (Aß) is accumulated as extracellular plaques in the gray matter of the brain, while in DM-2 islet amyloid polypeptide (IAPP) is accumulated in the pancreas. Premature cellular degeneration is seen in both diseases. Glucagon-like peptide-1 (GLP-1) reduces the amount of Aß and improves cognition in animal studies. The present study tests the hypothesis that treatment with the long-acting GLP-1 receptor agonist liraglutide affects the accumulation of Aß in patients with AD.

M3 - Journal article

C2 - 23158895

VL - 59

SP - A4519

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 10

ER -

ID: 44913415