Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. / Miskowiak, Kamilla Woznica; Vinberg, Maj; Macoveanu, Julian; Ehrenreich, Hannelore; Køster, Nicolai; Inkster, Becky; Paulson, Olaf B.; Kessing, Lars V.; Skimminge, Arnold; Siebner, Hartwig R.

In: Biological Psychiatry, Vol. 78, No. 4, 08.2015, p. 270-277.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Miskowiak, KW, Vinberg, M, Macoveanu, J, Ehrenreich, H, Køster, N, Inkster, B, Paulson, OB, Kessing, LV, Skimminge, A & Siebner, HR 2015, 'Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders', Biological Psychiatry, vol. 78, no. 4, pp. 270-277. https://doi.org/10.1016/j.biopsych.2014.12.013

APA

Miskowiak, K. W., Vinberg, M., Macoveanu, J., Ehrenreich, H., Køster, N., Inkster, B., Paulson, O. B., Kessing, L. V., Skimminge, A., & Siebner, H. R. (2015). Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. Biological Psychiatry, 78(4), 270-277. https://doi.org/10.1016/j.biopsych.2014.12.013

Vancouver

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B et al. Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. Biological Psychiatry. 2015 Aug;78(4):270-277. https://doi.org/10.1016/j.biopsych.2014.12.013

Author

Miskowiak, Kamilla Woznica ; Vinberg, Maj ; Macoveanu, Julian ; Ehrenreich, Hannelore ; Køster, Nicolai ; Inkster, Becky ; Paulson, Olaf B. ; Kessing, Lars V. ; Skimminge, Arnold ; Siebner, Hartwig R. / Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. In: Biological Psychiatry. 2015 ; Vol. 78, No. 4. pp. 270-277.

Bibtex

@article{375b752fc8594c7abe3e1bc0338b7dfd,
title = "Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders",
abstract = "BACKGROUND: Persistent cognitive dysfunction in depression and bipolar disorder (BD) impedes patients' functional recovery. Erythropoietin (EPO) increases neuroplasticity and reduces cognitive difficulties in treatment-resistant depression (TRD) and remitted BD. This magnetic resonance imaging study assessed the neuroanatomical basis for these effects.METHODS: Patients with TRD who were moderately depressed or BD in partial remission were randomized to 8 weekly EPO (40,000 IU) or saline infusions in a double-blind, parallel-group design. Patients underwent magnetic resonance imaging, memory assessment with the Rey Auditory Verbal Learning Test, and mood ratings with the Beck Depression Inventory, Hamilton Depression Rating Scale, and Young Mania Rating Scale at baseline and week 14. Hippocampus segmentation and analysis of hippocampal volume, shape, and gray matter density were conducted with FMRIB Software Library tools. Memory change was analyzed with repeated-measures analysis of covariance adjusted for depression symptoms, diagnosis, age, and gender.RESULTS: Eighty-four patients were randomized; 1 patient withdrew and data collection was incomplete for 14 patients; data were thus analyzed for 69 patients (EPO: n = 35, saline: n = 34). Compared with saline, EPO was associated with mood-independent memory improvement and reversal of brain matter loss in the left hippocampal cornu ammonis 1 to cornu ammonis 3 and subiculum. Using the entire sample, memory improvement was associated with subfield hippocampal volume increase independent of mood change.CONCLUSIONS: EPO-associated memory improvement in TRD and BD may be mediated by reversal of brain matter loss in a subfield of the left hippocampus. EPO may provide a therapeutic option for patients with mood disorders who have impaired neuroplasticity and cognition.",
keywords = "Adult, Bipolar Disorder, Depressive Disorder, Depressive Disorder, Treatment-Resistant, Erythropoietin, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Mood Disorders, Psychiatric Status Rating Scales",
author = "Miskowiak, {Kamilla Woznica} and Maj Vinberg and Julian Macoveanu and Hannelore Ehrenreich and Nicolai K{\o}ster and Becky Inkster and Paulson, {Olaf B.} and Kessing, {Lars V.} and Arnold Skimminge and Siebner, {Hartwig R.}",
note = "Copyright {\textcopyright} 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2015",
month = aug,
doi = "10.1016/j.biopsych.2014.12.013",
language = "English",
volume = "78",
pages = "270--277",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders

AU - Miskowiak, Kamilla Woznica

AU - Vinberg, Maj

AU - Macoveanu, Julian

AU - Ehrenreich, Hannelore

AU - Køster, Nicolai

AU - Inkster, Becky

AU - Paulson, Olaf B.

AU - Kessing, Lars V.

AU - Skimminge, Arnold

AU - Siebner, Hartwig R.

N1 - Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2015/8

Y1 - 2015/8

N2 - BACKGROUND: Persistent cognitive dysfunction in depression and bipolar disorder (BD) impedes patients' functional recovery. Erythropoietin (EPO) increases neuroplasticity and reduces cognitive difficulties in treatment-resistant depression (TRD) and remitted BD. This magnetic resonance imaging study assessed the neuroanatomical basis for these effects.METHODS: Patients with TRD who were moderately depressed or BD in partial remission were randomized to 8 weekly EPO (40,000 IU) or saline infusions in a double-blind, parallel-group design. Patients underwent magnetic resonance imaging, memory assessment with the Rey Auditory Verbal Learning Test, and mood ratings with the Beck Depression Inventory, Hamilton Depression Rating Scale, and Young Mania Rating Scale at baseline and week 14. Hippocampus segmentation and analysis of hippocampal volume, shape, and gray matter density were conducted with FMRIB Software Library tools. Memory change was analyzed with repeated-measures analysis of covariance adjusted for depression symptoms, diagnosis, age, and gender.RESULTS: Eighty-four patients were randomized; 1 patient withdrew and data collection was incomplete for 14 patients; data were thus analyzed for 69 patients (EPO: n = 35, saline: n = 34). Compared with saline, EPO was associated with mood-independent memory improvement and reversal of brain matter loss in the left hippocampal cornu ammonis 1 to cornu ammonis 3 and subiculum. Using the entire sample, memory improvement was associated with subfield hippocampal volume increase independent of mood change.CONCLUSIONS: EPO-associated memory improvement in TRD and BD may be mediated by reversal of brain matter loss in a subfield of the left hippocampus. EPO may provide a therapeutic option for patients with mood disorders who have impaired neuroplasticity and cognition.

AB - BACKGROUND: Persistent cognitive dysfunction in depression and bipolar disorder (BD) impedes patients' functional recovery. Erythropoietin (EPO) increases neuroplasticity and reduces cognitive difficulties in treatment-resistant depression (TRD) and remitted BD. This magnetic resonance imaging study assessed the neuroanatomical basis for these effects.METHODS: Patients with TRD who were moderately depressed or BD in partial remission were randomized to 8 weekly EPO (40,000 IU) or saline infusions in a double-blind, parallel-group design. Patients underwent magnetic resonance imaging, memory assessment with the Rey Auditory Verbal Learning Test, and mood ratings with the Beck Depression Inventory, Hamilton Depression Rating Scale, and Young Mania Rating Scale at baseline and week 14. Hippocampus segmentation and analysis of hippocampal volume, shape, and gray matter density were conducted with FMRIB Software Library tools. Memory change was analyzed with repeated-measures analysis of covariance adjusted for depression symptoms, diagnosis, age, and gender.RESULTS: Eighty-four patients were randomized; 1 patient withdrew and data collection was incomplete for 14 patients; data were thus analyzed for 69 patients (EPO: n = 35, saline: n = 34). Compared with saline, EPO was associated with mood-independent memory improvement and reversal of brain matter loss in the left hippocampal cornu ammonis 1 to cornu ammonis 3 and subiculum. Using the entire sample, memory improvement was associated with subfield hippocampal volume increase independent of mood change.CONCLUSIONS: EPO-associated memory improvement in TRD and BD may be mediated by reversal of brain matter loss in a subfield of the left hippocampus. EPO may provide a therapeutic option for patients with mood disorders who have impaired neuroplasticity and cognition.

KW - Adult

KW - Bipolar Disorder

KW - Depressive Disorder

KW - Depressive Disorder, Treatment-Resistant

KW - Erythropoietin

KW - Female

KW - Hippocampus

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - Middle Aged

KW - Mood Disorders

KW - Psychiatric Status Rating Scales

U2 - 10.1016/j.biopsych.2014.12.013

DO - 10.1016/j.biopsych.2014.12.013

M3 - Journal article

C2 - 25641635

VL - 78

SP - 270

EP - 277

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 4

ER -

ID: 162694071