Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis
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Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis. / Jensen, Peter; Zachariae, Claus; Christensen, Robin; Geiker, Nina Rica Wium; Schaadt, Bente K; Stender, Steen; Astrup, Arne; Hansen, Peter Riis; Skov, Lone.
In: Acta Dermatovenereologica, Vol. 94, No. 6, 2014, p. 691-694.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis
AU - Jensen, Peter
AU - Zachariae, Claus
AU - Christensen, Robin
AU - Geiker, Nina Rica Wium
AU - Schaadt, Bente K
AU - Stender, Steen
AU - Astrup, Arne
AU - Hansen, Peter Riis
AU - Skov, Lone
N1 - CURIS 2014 NEXS 102
PY - 2014
Y1 - 2014
N2 - Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.
AB - Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.
U2 - 10.2340/00015555-1824
DO - 10.2340/00015555-1824
M3 - Journal article
C2 - 24556829
VL - 94
SP - 691
EP - 694
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 6
ER -
ID: 105860577