Dynamic complex formation during the yeast cell cycle
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Dynamic complex formation during the yeast cell cycle. / de Lichtenberg, Ulrik; Jensen, Lars Juhl; Brunak, Søren; Bork, Peer.
In: Science (New York, N.Y.), Vol. 307, No. 5710, 2005, p. 724-7.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Dynamic complex formation during the yeast cell cycle
AU - de Lichtenberg, Ulrik
AU - Jensen, Lars Juhl
AU - Brunak, Søren
AU - Bork, Peer
PY - 2005
Y1 - 2005
N2 - To analyze the dynamics of protein complexes during the yeast cell cycle, we integrated data on protein interactions and gene expression. The resulting time-dependent interaction network places both periodically and constitutively expressed proteins in a temporal cell cycle context, thereby revealing previously unknown components and modules. We discovered that most complexes consist of both periodically and constitutively expressed subunits, which suggests that the former control complex activity by a mechanism of just-in-time assembly. Consistent with this, we show that additional regulation through targeted degradation and phosphorylation by Cdc28p (Cdk1) specifically affects the periodically expressed proteins.
AB - To analyze the dynamics of protein complexes during the yeast cell cycle, we integrated data on protein interactions and gene expression. The resulting time-dependent interaction network places both periodically and constitutively expressed proteins in a temporal cell cycle context, thereby revealing previously unknown components and modules. We discovered that most complexes consist of both periodically and constitutively expressed subunits, which suggests that the former control complex activity by a mechanism of just-in-time assembly. Consistent with this, we show that additional regulation through targeted degradation and phosphorylation by Cdc28p (Cdk1) specifically affects the periodically expressed proteins.
U2 - 10.1126/science.1105103
DO - 10.1126/science.1105103
M3 - Journal article
C2 - 15692050
VL - 307
SP - 724
EP - 727
JO - Science
JF - Science
SN - 0036-8075
IS - 5710
ER -
ID: 40740621