DNA polymorphism of HLA class II genes in systemic lupus erythematosus
Research output: Contribution to journal › Journal article › Research › peer-review
We investigated the DNA restriction fragment length polymorphism (RFLP) of the major histocompatibility complex (MHC) genes: HLA-DRB, -DQA, -DQB, -DPB in 24 Danish patients with systemic lupus erythematosus (SLE) and in 102 healthy Danes. A highly significant increase of the frequency of the DR3- and DRw6-associated 7.00 kb DRB TaqI DNA fragment was found in SLE patients compared to normal controls (83.3% vs 35.5%; RR = 9.1, p < 10(-4). The frequencies of the DQA1*0501-associated 4.56 kb DQA TaqI fragment and the DRB3*01/03-associated 9.79 kb TaqI fragment were also found to be significantly increased in SLE patients (70.8% vs 29.7%; RR = 5.8, p < 10(-2) for the DQA fragment and 70.8% vs 36.1%; RR = 4.3, p < 0.05 for the DRB3 fragment). Less extensive and insignificant increases of the frequencies of the DR3-associated DQB and DPB fragments were observed. The frequencies of the DR2-associated DRB, DQA, and DQB fragments were comparable to those found in normal controls.
Original language | English |
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Journal | HLA |
Volume | 43 |
Issue number | 1 |
Pages (from-to) | 34-7 |
Number of pages | 3 |
ISSN | 2059-2302 |
Publication status | Published - 1994 |
Bibliographical note
Keywords: DNA; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; Histocompatibility Antigens Class II; Humans; Lupus Erythematosus, Systemic; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
ID: 16186192