DNA damage invokes mitophagy through a pathway involving Spata18

Research output: Contribution to journalJournal articlepeer-review

Standard

DNA damage invokes mitophagy through a pathway involving Spata18. / Dan, Xiuli; Babbar, Mansi; Moore, Anthony; Wechter, Noah; Tian, Jingyan; Mohanty, Joy G; Croteau, Deborah L; Bohr, Vilhelm A.

In: Nucleic Acids Research, Vol. 48, No. 12, 2020, p. 6611-6623.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Dan, X, Babbar, M, Moore, A, Wechter, N, Tian, J, Mohanty, JG, Croteau, DL & Bohr, VA 2020, 'DNA damage invokes mitophagy through a pathway involving Spata18', Nucleic Acids Research, vol. 48, no. 12, pp. 6611-6623. https://doi.org/10.1093/nar/gkaa393

APA

Dan, X., Babbar, M., Moore, A., Wechter, N., Tian, J., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2020). DNA damage invokes mitophagy through a pathway involving Spata18. Nucleic Acids Research, 48(12), 6611-6623. https://doi.org/10.1093/nar/gkaa393

Vancouver

Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG et al. DNA damage invokes mitophagy through a pathway involving Spata18. Nucleic Acids Research. 2020;48(12):6611-6623. https://doi.org/10.1093/nar/gkaa393

Author

Dan, Xiuli ; Babbar, Mansi ; Moore, Anthony ; Wechter, Noah ; Tian, Jingyan ; Mohanty, Joy G ; Croteau, Deborah L ; Bohr, Vilhelm A. / DNA damage invokes mitophagy through a pathway involving Spata18. In: Nucleic Acids Research. 2020 ; Vol. 48, No. 12. pp. 6611-6623.

Bibtex

@article{9b3bb1b6d38e4303a4543872d0281908,
title = "DNA damage invokes mitophagy through a pathway involving Spata18",
abstract = "Mitochondria are vital for cellular energy supply and intracellular signaling after stress. Here, we aimed to investigate how mitochondria respond to acute DNA damage with respect to mitophagy, which is an important mitochondrial quality control process. Our results show that mitophagy increases after DNA damage in primary fibroblasts, murine neurons and Caenorhabditis elegans neurons. Our results indicate that modulation of mitophagy after DNA damage is independent of the type of DNA damage stimuli used and that the protein Spata18 is an important player in this process. Knockdown of Spata18 suppresses mitophagy, disturbs mitochondrial Ca2+ homeostasis, affects ATP production, and attenuates DNA repair. Importantly, mitophagy after DNA damage is a vital cellular response to maintain mitochondrial functions and DNA repair.",
keywords = "Animals, Caenorhabditis elegans/genetics, Calcium/metabolism, Cell Line, Cell Proliferation/genetics, DNA Damage/genetics, DNA Repair/genetics, Fibroblasts/metabolism, Humans, Mice, Mitochondria/genetics, Mitochondrial Proteins/genetics, Mitophagy/genetics, Neurons/metabolism",
author = "Xiuli Dan and Mansi Babbar and Anthony Moore and Noah Wechter and Jingyan Tian and Mohanty, {Joy G} and Croteau, {Deborah L} and Bohr, {Vilhelm A}",
note = "Published by Oxford University Press on behalf of Nucleic Acids Research 2020.",
year = "2020",
doi = "10.1093/nar/gkaa393",
language = "English",
volume = "48",
pages = "6611--6623",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - DNA damage invokes mitophagy through a pathway involving Spata18

AU - Dan, Xiuli

AU - Babbar, Mansi

AU - Moore, Anthony

AU - Wechter, Noah

AU - Tian, Jingyan

AU - Mohanty, Joy G

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

N1 - Published by Oxford University Press on behalf of Nucleic Acids Research 2020.

PY - 2020

Y1 - 2020

N2 - Mitochondria are vital for cellular energy supply and intracellular signaling after stress. Here, we aimed to investigate how mitochondria respond to acute DNA damage with respect to mitophagy, which is an important mitochondrial quality control process. Our results show that mitophagy increases after DNA damage in primary fibroblasts, murine neurons and Caenorhabditis elegans neurons. Our results indicate that modulation of mitophagy after DNA damage is independent of the type of DNA damage stimuli used and that the protein Spata18 is an important player in this process. Knockdown of Spata18 suppresses mitophagy, disturbs mitochondrial Ca2+ homeostasis, affects ATP production, and attenuates DNA repair. Importantly, mitophagy after DNA damage is a vital cellular response to maintain mitochondrial functions and DNA repair.

AB - Mitochondria are vital for cellular energy supply and intracellular signaling after stress. Here, we aimed to investigate how mitochondria respond to acute DNA damage with respect to mitophagy, which is an important mitochondrial quality control process. Our results show that mitophagy increases after DNA damage in primary fibroblasts, murine neurons and Caenorhabditis elegans neurons. Our results indicate that modulation of mitophagy after DNA damage is independent of the type of DNA damage stimuli used and that the protein Spata18 is an important player in this process. Knockdown of Spata18 suppresses mitophagy, disturbs mitochondrial Ca2+ homeostasis, affects ATP production, and attenuates DNA repair. Importantly, mitophagy after DNA damage is a vital cellular response to maintain mitochondrial functions and DNA repair.

KW - Animals

KW - Caenorhabditis elegans/genetics

KW - Calcium/metabolism

KW - Cell Line

KW - Cell Proliferation/genetics

KW - DNA Damage/genetics

KW - DNA Repair/genetics

KW - Fibroblasts/metabolism

KW - Humans

KW - Mice

KW - Mitochondria/genetics

KW - Mitochondrial Proteins/genetics

KW - Mitophagy/genetics

KW - Neurons/metabolism

U2 - 10.1093/nar/gkaa393

DO - 10.1093/nar/gkaa393

M3 - Journal article

C2 - 32453416

VL - 48

SP - 6611

EP - 6623

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 12

ER -

ID: 257866027