Divergent picornavirus IRES elements

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Divergent picornavirus IRES elements. / Belsham, Graham J.

In: Virus Research, Vol. 139, No. 2, 02.2009, p. 183-92.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Belsham, GJ 2009, 'Divergent picornavirus IRES elements', Virus Research, vol. 139, no. 2, pp. 183-92. https://doi.org/10.1016/j.virusres.2008.07.001

APA

Belsham, G. J. (2009). Divergent picornavirus IRES elements. Virus Research, 139(2), 183-92. https://doi.org/10.1016/j.virusres.2008.07.001

Vancouver

Belsham GJ. Divergent picornavirus IRES elements. Virus Research. 2009 Feb;139(2):183-92. https://doi.org/10.1016/j.virusres.2008.07.001

Author

Belsham, Graham J. / Divergent picornavirus IRES elements. In: Virus Research. 2009 ; Vol. 139, No. 2. pp. 183-92.

Bibtex

@article{e6aaa4a6edd340d2a08922930ee1add8,
title = "Divergent picornavirus IRES elements",
abstract = "Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four classes of IRES element which vary in size (450-270 nt), they also have different, complex, secondary structures and distinct requirements for cellular proteins to allow them to function. This review describes the features of each class of picornavirus IRES element but focuses on the characteristics of the most recently described group, initially identified within the porcine teschovirus-1 RNA, which has strong similarities to the IRES elements from within the genomes of hepatitis C virus and the pestiviruses which are members of the flavivirus family. The selection of the initiation codon by these distinct IRES elements is also discussed.",
keywords = "Base Sequence, Codon, Initiator, Genome, Viral, Molecular Sequence Data, Nucleic Acid Conformation, Peptide Chain Initiation, Translational, Picornaviridae/genetics, RNA, Viral/chemistry, Ribosomes/chemistry",
author = "Belsham, {Graham J}",
year = "2009",
month = feb,
doi = "10.1016/j.virusres.2008.07.001",
language = "English",
volume = "139",
pages = "183--92",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Divergent picornavirus IRES elements

AU - Belsham, Graham J

PY - 2009/2

Y1 - 2009/2

N2 - Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four classes of IRES element which vary in size (450-270 nt), they also have different, complex, secondary structures and distinct requirements for cellular proteins to allow them to function. This review describes the features of each class of picornavirus IRES element but focuses on the characteristics of the most recently described group, initially identified within the porcine teschovirus-1 RNA, which has strong similarities to the IRES elements from within the genomes of hepatitis C virus and the pestiviruses which are members of the flavivirus family. The selection of the initiation codon by these distinct IRES elements is also discussed.

AB - Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four classes of IRES element which vary in size (450-270 nt), they also have different, complex, secondary structures and distinct requirements for cellular proteins to allow them to function. This review describes the features of each class of picornavirus IRES element but focuses on the characteristics of the most recently described group, initially identified within the porcine teschovirus-1 RNA, which has strong similarities to the IRES elements from within the genomes of hepatitis C virus and the pestiviruses which are members of the flavivirus family. The selection of the initiation codon by these distinct IRES elements is also discussed.

KW - Base Sequence

KW - Codon, Initiator

KW - Genome, Viral

KW - Molecular Sequence Data

KW - Nucleic Acid Conformation

KW - Peptide Chain Initiation, Translational

KW - Picornaviridae/genetics

KW - RNA, Viral/chemistry

KW - Ribosomes/chemistry

U2 - 10.1016/j.virusres.2008.07.001

DO - 10.1016/j.virusres.2008.07.001

M3 - Review

C2 - 18675861

VL - 139

SP - 183

EP - 192

JO - Virus Research

JF - Virus Research

SN - 0168-1702

IS - 2

ER -

ID: 257918374