Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. / Lindgren, O; Carr, RD; Holst, Jens Juul; Deacon, Carolyn F.; Ahren, B.

In: Diabetes, Obesity and Metabolism Online, Vol. 13, No. 9, 07.2011, p. 863-865.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lindgren, O, Carr, RD, Holst, JJ, Deacon, CF & Ahren, B 2011, 'Dissociated incretin hormone response to protein versus fat ingestion in obese subjects', Diabetes, Obesity and Metabolism Online, vol. 13, no. 9, pp. 863-865. https://doi.org/10.1111/j.1463-1326.2011.01420.x

APA

Lindgren, O., Carr, RD., Holst, J. J., Deacon, C. F., & Ahren, B. (2011). Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. Diabetes, Obesity and Metabolism Online, 13(9), 863-865. https://doi.org/10.1111/j.1463-1326.2011.01420.x

Vancouver

Lindgren O, Carr RD, Holst JJ, Deacon CF, Ahren B. Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. Diabetes, Obesity and Metabolism Online. 2011 Jul;13(9):863-865. https://doi.org/10.1111/j.1463-1326.2011.01420.x

Author

Lindgren, O ; Carr, RD ; Holst, Jens Juul ; Deacon, Carolyn F. ; Ahren, B. / Dissociated incretin hormone response to protein versus fat ingestion in obese subjects. In: Diabetes, Obesity and Metabolism Online. 2011 ; Vol. 13, No. 9. pp. 863-865.

Bibtex

@article{8acbcbb40475495587e142b2db9e73ac,
title = "Dissociated incretin hormone response to protein versus fat ingestion in obese subjects",
abstract = "Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.",
keywords = "Adult, Dietary Fats, Dietary Proteins, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Humans, Incretins, Male, Obesity",
author = "O Lindgren and RD Carr and Holst, {Jens Juul} and Deacon, {Carolyn F.} and B Ahren",
note = "{\textcopyright} 2011 Blackwell Publishing Ltd.",
year = "2011",
month = jul,
doi = "10.1111/j.1463-1326.2011.01420.x",
language = "English",
volume = "13",
pages = "863--865",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

AU - Lindgren, O

AU - Carr, RD

AU - Holst, Jens Juul

AU - Deacon, Carolyn F.

AU - Ahren, B

N1 - © 2011 Blackwell Publishing Ltd.

PY - 2011/7

Y1 - 2011/7

N2 - Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.

AB - Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.

KW - Adult

KW - Dietary Fats

KW - Dietary Proteins

KW - Gastric Inhibitory Polypeptide

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Incretins

KW - Male

KW - Obesity

U2 - 10.1111/j.1463-1326.2011.01420.x

DO - 10.1111/j.1463-1326.2011.01420.x

M3 - Journal article

C2 - 21554523

VL - 13

SP - 863

EP - 865

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 9

ER -

ID: 38186440