Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

Research output: Contribution to journalJournal articleResearchpeer-review

Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.
Original languageEnglish
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Issue number10
Pages (from-to)1640-8
Number of pages9
Publication statusPublished - Oct 2007

    Research areas

  • Acids, Adrenal Medulla, Animals, Biological Transport, Bone Resorption, Cattle, Cell Survival, Cells, Cultured, Dioxolanes, Enzyme Inhibitors, Humans, Hydrogen-Ion Concentration, Lignans, Molecular Structure, Osteoclasts, Vacuolar Proton-Translocating ATPases

ID: 47555975