Diminished concentrations of insulin-like growth factor I in cystic fibrosis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Diminished concentrations of insulin-like growth factor I in cystic fibrosis. / Laursen, Erik; Juul, A; Lanng, S; Høiby, N; Koch, C; Müller, J; Skakkebaek, N E.

In: Archives of Disease in Childhood. Education and Practice Edition, Vol. 72, No. 6, 1995, p. 494-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laursen, E, Juul, A, Lanng, S, Høiby, N, Koch, C, Müller, J & Skakkebaek, NE 1995, 'Diminished concentrations of insulin-like growth factor I in cystic fibrosis', Archives of Disease in Childhood. Education and Practice Edition, vol. 72, no. 6, pp. 494-7.

APA

Laursen, E., Juul, A., Lanng, S., Høiby, N., Koch, C., Müller, J., & Skakkebaek, N. E. (1995). Diminished concentrations of insulin-like growth factor I in cystic fibrosis. Archives of Disease in Childhood. Education and Practice Edition, 72(6), 494-7.

Vancouver

Laursen E, Juul A, Lanng S, Høiby N, Koch C, Müller J et al. Diminished concentrations of insulin-like growth factor I in cystic fibrosis. Archives of Disease in Childhood. Education and Practice Edition. 1995;72(6):494-7.

Author

Laursen, Erik ; Juul, A ; Lanng, S ; Høiby, N ; Koch, C ; Müller, J ; Skakkebaek, N E. / Diminished concentrations of insulin-like growth factor I in cystic fibrosis. In: Archives of Disease in Childhood. Education and Practice Edition. 1995 ; Vol. 72, No. 6. pp. 494-7.

Bibtex

@article{1bfd90f89d5343d7bb362e21dc011953,
title = "Diminished concentrations of insulin-like growth factor I in cystic fibrosis",
abstract = "Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p <0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.",
author = "Erik Laursen and A Juul and S Lanng and N H{\o}iby and C Koch and J M{\"u}ller and Skakkebaek, {N E}",
year = "1995",
language = "English",
volume = "72",
pages = "494--7",
journal = "Archives of Disease in Childhood",
issn = "1743-0585",
publisher = "B M J Group",
number = "6",

}

RIS

TY - JOUR

T1 - Diminished concentrations of insulin-like growth factor I in cystic fibrosis

AU - Laursen, Erik

AU - Juul, A

AU - Lanng, S

AU - Høiby, N

AU - Koch, C

AU - Müller, J

AU - Skakkebaek, N E

PY - 1995

Y1 - 1995

N2 - Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p <0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.

AB - Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p <0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.

M3 - Journal article

VL - 72

SP - 494

EP - 497

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 1743-0585

IS - 6

ER -

ID: 48486631