Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA
Research output: Contribution to journal › Journal article › Research › peer-review
In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 6 |
| Issue number | 3 |
| Pages (from-to) | e17942 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 1 Jan 2011 |
- Animals, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Epitopes, Erythrocytes, Female, Humans, Immunoglobulin G, Malaria Vaccines, Malaria, Falciparum, Mice, Placenta, Plasmodium falciparum, Pregnancy, Protein Array Analysis, Protein Structure, Tertiary, Rabbits, Rats, Recombinant Proteins, Species Specificity
Research areas
ID: 35277138