Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder : A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11. / Gregersen, Maja; Møllegaard Jepsen, Jens Richardt; Rohd, Sinnika Birkehøj; Søndergaard, Anne; Brandt, Julie Marie; Ellersgaard, Ditte; Hjorthøj, Carsten; Ohland, Jessica; Krantz, Mette Falkenberg; Wilms, Martin; Andreassen, Anna Krogh; Veddum, Lotte; Knudsen, Christina Bruun; Greve, Aja Neergaard; Bliksted, Vibeke; Mors, Ole; Clemmensen, Lars; Nordentoft, Merete; Hemager, Nicoline; Elgaard Thorup, Anne Amalie.

In: The American Journal of Psychiatry, Vol. 179, No. 9, 2022, p. 628-639.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gregersen, M, Møllegaard Jepsen, JR, Rohd, SB, Søndergaard, A, Brandt, JM, Ellersgaard, D, Hjorthøj, C, Ohland, J, Krantz, MF, Wilms, M, Andreassen, AK, Veddum, L, Knudsen, CB, Greve, AN, Bliksted, V, Mors, O, Clemmensen, L, Nordentoft, M, Hemager, N & Elgaard Thorup, AA 2022, 'Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11', The American Journal of Psychiatry, vol. 179, no. 9, pp. 628-639. https://doi.org/10.1176/appi.ajp.21101076

APA

Gregersen, M., Møllegaard Jepsen, J. R., Rohd, S. B., Søndergaard, A., Brandt, J. M., Ellersgaard, D., Hjorthøj, C., Ohland, J., Krantz, M. F., Wilms, M., Andreassen, A. K., Veddum, L., Knudsen, C. B., Greve, A. N., Bliksted, V., Mors, O., Clemmensen, L., Nordentoft, M., Hemager, N., & Elgaard Thorup, A. A. (2022). Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11. The American Journal of Psychiatry, 179(9), 628-639. https://doi.org/10.1176/appi.ajp.21101076

Vancouver

Gregersen M, Møllegaard Jepsen JR, Rohd SB, Søndergaard A, Brandt JM, Ellersgaard D et al. Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11. The American Journal of Psychiatry. 2022;179(9):628-639. https://doi.org/10.1176/appi.ajp.21101076

Author

Gregersen, Maja ; Møllegaard Jepsen, Jens Richardt ; Rohd, Sinnika Birkehøj ; Søndergaard, Anne ; Brandt, Julie Marie ; Ellersgaard, Ditte ; Hjorthøj, Carsten ; Ohland, Jessica ; Krantz, Mette Falkenberg ; Wilms, Martin ; Andreassen, Anna Krogh ; Veddum, Lotte ; Knudsen, Christina Bruun ; Greve, Aja Neergaard ; Bliksted, Vibeke ; Mors, Ole ; Clemmensen, Lars ; Nordentoft, Merete ; Hemager, Nicoline ; Elgaard Thorup, Anne Amalie. / Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder : A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11. In: The American Journal of Psychiatry. 2022 ; Vol. 179, No. 9. pp. 628-639.

Bibtex

@article{cae4378aea29418cb93a047c7ab0696e,
title = "Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11",
abstract = "OBJECTIVE: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. We examined the prevalence of psychotic experiences in middle childhood and whether early childhood psychotic experiences and developmental pathways of psychotic experiences predicted mental disorders in middle childhood in children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and a population-based control group. METHODS: In a longitudinal population-based cohort study children at FHR-SZ (N=170), FHR-BP (N=103), and the control group (N=174) were assessed for psychotic experiences and axis I disorders with face-to-face interviews in early and middle childhood (at 7 and 11 years of age). RESULTS: Psychotic experiences were more prevalent in children at FHR-SZ (31.8%, odds ratio 2.1, 95% CI 1.3-3.4) than in the control group (18.4%) in middle childhood. Early childhood psychotic experiences predicted mental disorders in middle childhood after adjusting for early childhood disorders and familial risk (odds ratio 2.0, 95% CI 1.2-3.1). Having three or more psychotic experiences increased odds the most (odds ratio 2.5, 95% CI 1.1-5.7). Persistent psychotic experiences were associated with increased odds of middle childhood disorders (odds ratio 4.1, 95% CI 2.1-8.4). Psychotic experiences were nondifferentially associated with mental disorders across the three familial risk groups. CONCLUSIONS: Early childhood psychotic experiences predict mental disorders in middle childhood. Psychotic experiences index vulnerability for psychopathology nondifferentially in children at familial high risk and the control group. Psychotic experiences should be included in mental health screenings including children at familial high risk.",
keywords = "Bipolar and Related Disorders, Child/Adolescent Psychiatry, Schizophrenia Spectrum and Other Psychotic Disorders",
author = "Maja Gregersen and {M{\o}llegaard Jepsen}, {Jens Richardt} and Rohd, {Sinnika Birkeh{\o}j} and Anne S{\o}ndergaard and Brandt, {Julie Marie} and Ditte Ellersgaard and Carsten Hjorth{\o}j and Jessica Ohland and Krantz, {Mette Falkenberg} and Martin Wilms and Andreassen, {Anna Krogh} and Lotte Veddum and Knudsen, {Christina Bruun} and Greve, {Aja Neergaard} and Vibeke Bliksted and Ole Mors and Lars Clemmensen and Merete Nordentoft and Nicoline Hemager and {Elgaard Thorup}, {Anne Amalie}",
year = "2022",
doi = "10.1176/appi.ajp.21101076",
language = "English",
volume = "179",
pages = "628--639",
journal = "The American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Publishing, Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder

T2 - A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11

AU - Gregersen, Maja

AU - Møllegaard Jepsen, Jens Richardt

AU - Rohd, Sinnika Birkehøj

AU - Søndergaard, Anne

AU - Brandt, Julie Marie

AU - Ellersgaard, Ditte

AU - Hjorthøj, Carsten

AU - Ohland, Jessica

AU - Krantz, Mette Falkenberg

AU - Wilms, Martin

AU - Andreassen, Anna Krogh

AU - Veddum, Lotte

AU - Knudsen, Christina Bruun

AU - Greve, Aja Neergaard

AU - Bliksted, Vibeke

AU - Mors, Ole

AU - Clemmensen, Lars

AU - Nordentoft, Merete

AU - Hemager, Nicoline

AU - Elgaard Thorup, Anne Amalie

PY - 2022

Y1 - 2022

N2 - OBJECTIVE: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. We examined the prevalence of psychotic experiences in middle childhood and whether early childhood psychotic experiences and developmental pathways of psychotic experiences predicted mental disorders in middle childhood in children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and a population-based control group. METHODS: In a longitudinal population-based cohort study children at FHR-SZ (N=170), FHR-BP (N=103), and the control group (N=174) were assessed for psychotic experiences and axis I disorders with face-to-face interviews in early and middle childhood (at 7 and 11 years of age). RESULTS: Psychotic experiences were more prevalent in children at FHR-SZ (31.8%, odds ratio 2.1, 95% CI 1.3-3.4) than in the control group (18.4%) in middle childhood. Early childhood psychotic experiences predicted mental disorders in middle childhood after adjusting for early childhood disorders and familial risk (odds ratio 2.0, 95% CI 1.2-3.1). Having three or more psychotic experiences increased odds the most (odds ratio 2.5, 95% CI 1.1-5.7). Persistent psychotic experiences were associated with increased odds of middle childhood disorders (odds ratio 4.1, 95% CI 2.1-8.4). Psychotic experiences were nondifferentially associated with mental disorders across the three familial risk groups. CONCLUSIONS: Early childhood psychotic experiences predict mental disorders in middle childhood. Psychotic experiences index vulnerability for psychopathology nondifferentially in children at familial high risk and the control group. Psychotic experiences should be included in mental health screenings including children at familial high risk.

AB - OBJECTIVE: Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of psychotic experiences in children and adolescents at familial high risk of psychosis. We examined the prevalence of psychotic experiences in middle childhood and whether early childhood psychotic experiences and developmental pathways of psychotic experiences predicted mental disorders in middle childhood in children at familial high risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and a population-based control group. METHODS: In a longitudinal population-based cohort study children at FHR-SZ (N=170), FHR-BP (N=103), and the control group (N=174) were assessed for psychotic experiences and axis I disorders with face-to-face interviews in early and middle childhood (at 7 and 11 years of age). RESULTS: Psychotic experiences were more prevalent in children at FHR-SZ (31.8%, odds ratio 2.1, 95% CI 1.3-3.4) than in the control group (18.4%) in middle childhood. Early childhood psychotic experiences predicted mental disorders in middle childhood after adjusting for early childhood disorders and familial risk (odds ratio 2.0, 95% CI 1.2-3.1). Having three or more psychotic experiences increased odds the most (odds ratio 2.5, 95% CI 1.1-5.7). Persistent psychotic experiences were associated with increased odds of middle childhood disorders (odds ratio 4.1, 95% CI 2.1-8.4). Psychotic experiences were nondifferentially associated with mental disorders across the three familial risk groups. CONCLUSIONS: Early childhood psychotic experiences predict mental disorders in middle childhood. Psychotic experiences index vulnerability for psychopathology nondifferentially in children at familial high risk and the control group. Psychotic experiences should be included in mental health screenings including children at familial high risk.

KW - Bipolar and Related Disorders

KW - Child/Adolescent Psychiatry

KW - Schizophrenia Spectrum and Other Psychotic Disorders

U2 - 10.1176/appi.ajp.21101076

DO - 10.1176/appi.ajp.21101076

M3 - Journal article

C2 - 36048497

AN - SCOPUS:85137136184

VL - 179

SP - 628

EP - 639

JO - The American Journal of Psychiatry

JF - The American Journal of Psychiatry

SN - 0002-953X

IS - 9

ER -

ID: 320654794