Cysteinylleukotrieners betydning for kronisk inflammation og neoplasi i tarmen

Research output: Contribution to journalJournal articleResearchpeer-review

It has recently been demonstrated that cysteinyl leukotrienes are involved in a variety of proinflammatory and neoplastic functions. This article gives an up-to-date overview of the present knowledge of these bioactive lipid molecules. Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are applied as models of their cellular actions. It is described how signalling cascades initiated by cysteinyl leukotrienes represent alternative ways in which IBD might progress and lead to the development and propagation of CRC, and as such represent potential targets for future therapeutic regimens to manage chronic inflammatory disorders and cancer.
Udgivelsesdato: 2009-Jan-19
Original languageDanish
JournalUgeskrift for læger
Volume171
Issue number4
Pages (from-to)243-6
Number of pages3
ISSN0041-5782
Publication statusPublished - 2009

Bibliographical note

Keywords: Cell Membrane; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Leukotriene D4; Leukotrienes; Receptors, Leukotriene; Signal Transduction

ID: 18813266