Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
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Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis. / Koppes, Sjors A.; Engebretsen, Kristiane A.; Agner, Tove; Angelova-Fischer, Irena; Berents, Teresa; Brandner, Johanna; Brans, Richard; Clausen, Maja Lisa; Hummler, Edith; Jakasa, Ivone; Jurakić-Tončic, Ružica; John, Swen M.; Khnykin, Denis; Molin, Sonja; Holm, Jan O.; Suomela, Sari; Thierse, Hermann Josef; Kezic, Sanja; Martin, Stefan F.; Thyssen, Jacob P.
In: Contact Dermatitis, Vol. 77, No. 1, 07.2017, p. 1-16.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
AU - Koppes, Sjors A.
AU - Engebretsen, Kristiane A.
AU - Agner, Tove
AU - Angelova-Fischer, Irena
AU - Berents, Teresa
AU - Brandner, Johanna
AU - Brans, Richard
AU - Clausen, Maja Lisa
AU - Hummler, Edith
AU - Jakasa, Ivone
AU - Jurakić-Tončic, Ružica
AU - John, Swen M.
AU - Khnykin, Denis
AU - Molin, Sonja
AU - Holm, Jan O.
AU - Suomela, Sari
AU - Thierse, Hermann Josef
AU - Kezic, Sanja
AU - Martin, Stefan F.
AU - Thyssen, Jacob P.
PY - 2017/7
Y1 - 2017/7
N2 - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.
AB - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.
KW - allergic contact dermatitis
KW - biomarkers
KW - contact allergy
KW - contact sensitization
U2 - 10.1111/cod.12789
DO - 10.1111/cod.12789
M3 - Review
C2 - 28497472
AN - SCOPUS:85018897672
VL - 77
SP - 1
EP - 16
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 1
ER -
ID: 196440791