Crystallization of Piroxicam Solid Forms and the Effects of Additives
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Crystallization of Piroxicam Solid Forms and the Effects of Additives. / Liu, Guangpu; Hansen, Thomas B.; Qu, Haiyan; Yang, Mingshi; Pajander, Jari P.; Rantanen, Jukka; Christensen, Lars P.
In: Chemical Engineering and Technology, Vol. 37, No. 8, 2014, p. 1297-1304.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Crystallization of Piroxicam Solid Forms and the Effects of Additives
AU - Liu, Guangpu
AU - Hansen, Thomas B.
AU - Qu, Haiyan
AU - Yang, Mingshi
AU - Pajander, Jari P.
AU - Rantanen, Jukka
AU - Christensen, Lars P.
PY - 2014
Y1 - 2014
N2 - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.
AB - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.
KW - Crystallization
KW - Effect of additives
KW - Monohydrate
KW - Pharmaceutical products
KW - Polymorphism
KW - Relative thermodynamic stability
U2 - 10.1002/ceat.201400206
DO - 10.1002/ceat.201400206
M3 - Journal article
AN - SCOPUS:84904806350
VL - 37
SP - 1297
EP - 1304
JO - Chemical Engineering and Technology
JF - Chemical Engineering and Technology
SN - 0930-7516
IS - 8
ER -
ID: 221827548