Crystallization and preliminary X-ray analysis of a PNA-DNA complex

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Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.

Original languageEnglish
JournalFEBS letters
Issue number1-2
Pages (from-to)115-7
Number of pages3
Publication statusPublished - 17 Apr 1995

    Research areas

  • Base Sequence, Crystallization, Crystallography, X-Ray, DNA/chemistry, Molecular Sequence Data, Oligodeoxyribonucleotides/chemistry

ID: 203633519