C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease
Research output: Contribution to journal › Journal article › Research › peer-review
We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.
Original language | English |
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Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
Volume | 69 |
Issue number | 4 |
Pages (from-to) | 442-6 |
Number of pages | 5 |
ISSN | 0036-5513 |
DOIs | |
Publication status | Published - 2009 |
Bibliographical note
Keywords: C-Reactive Protein; Cerebrovascular Disorders; Humans; Myocardial Ischemia; Risk Factors
ID: 20569680