C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease

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RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP). OBJECTIVE: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD. METHODS: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study. MEASUREMENTS AND MAIN RESULTS: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L (log rank: p <0.001). (1.2-3.9) (95% 1.0-2.0) 1.4 2.2 adjusting after age, and at baseline confidence consumption, copd crp death disease, due fev(1)% for hazard heart hospitalization in increased individuals interval, ischemic predicted, ratios sex, the to tobacco were with> 3 mg/L versus < or = 3 mg/L. After close matching for FEV(1)% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV(1)% predicted of less than 50. CONCLUSIONS: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.
Original languageEnglish
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number3
Pages (from-to)250-5
Number of pages6
Publication statusPublished - 2007

    Research areas

  • Aged, Biological Markers, C-Reactive Protein, Cohort Studies, Female, Hospitalization, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Prognosis, Pulmonary Disease, Chronic Obstructive, Risk

ID: 34121581