Copeptin levels and invasive hemodynamics in patients with advanced heart failure

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Copeptin levels and invasive hemodynamics in patients with advanced heart failure. / Balling, Louise; Goetze, Jens Peter; Jung, Mette Holme; Rossing, Kasper; Boesgaard, Soeren; Gustafsson, Finn.

In: Biomarkers in Medicine, Vol. 12, No. 8, 2018, p. 861-870.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Balling, L, Goetze, JP, Jung, MH, Rossing, K, Boesgaard, S & Gustafsson, F 2018, 'Copeptin levels and invasive hemodynamics in patients with advanced heart failure', Biomarkers in Medicine, vol. 12, no. 8, pp. 861-870. https://doi.org/10.2217/bmm-2017-0439

APA

Balling, L., Goetze, J. P., Jung, M. H., Rossing, K., Boesgaard, S., & Gustafsson, F. (2018). Copeptin levels and invasive hemodynamics in patients with advanced heart failure. Biomarkers in Medicine, 12(8), 861-870. https://doi.org/10.2217/bmm-2017-0439

Vancouver

Balling L, Goetze JP, Jung MH, Rossing K, Boesgaard S, Gustafsson F. Copeptin levels and invasive hemodynamics in patients with advanced heart failure. Biomarkers in Medicine. 2018;12(8):861-870. https://doi.org/10.2217/bmm-2017-0439

Author

Balling, Louise ; Goetze, Jens Peter ; Jung, Mette Holme ; Rossing, Kasper ; Boesgaard, Soeren ; Gustafsson, Finn. / Copeptin levels and invasive hemodynamics in patients with advanced heart failure. In: Biomarkers in Medicine. 2018 ; Vol. 12, No. 8. pp. 861-870.

Bibtex

@article{d41d8b241a5b4b0599e9b8cc791c3da7,
title = "Copeptin levels and invasive hemodynamics in patients with advanced heart failure",
abstract = "AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.",
author = "Louise Balling and Goetze, {Jens Peter} and Jung, {Mette Holme} and Kasper Rossing and Soeren Boesgaard and Finn Gustafsson",
year = "2018",
doi = "10.2217/bmm-2017-0439",
language = "English",
volume = "12",
pages = "861--870",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Copeptin levels and invasive hemodynamics in patients with advanced heart failure

AU - Balling, Louise

AU - Goetze, Jens Peter

AU - Jung, Mette Holme

AU - Rossing, Kasper

AU - Boesgaard, Soeren

AU - Gustafsson, Finn

PY - 2018

Y1 - 2018

N2 - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.

AB - AIM: Arginine vasopressin is a potent vasoconstrictory hormone and arginine vasopressin release is upregulated in heart failure (HF). The aim of this study was to evaluate if copeptin (the C-terminal part of provasopressin) is related to invasive hemodynamics in HF.METHODS & RESULTS: Right heart catheterization was performed in patients with advanced HF referred for evaluation for heart transplantation. Sixty-five patients (mean age 54 ± 12 years, left ventricular ejection fraction 19 ± 8% and median copeptin levels of 16.7 pmol/l (interquartile range: 11-30 pmol/l) were included. In multivariate analysis, increased levels of log (copeptin) were associated with a reduced CI (r = 0.65 and p = 0.04).CONCLUSION: Increased copeptin levels in plasma are associated with hemodynamic parameters obtained at right heart catheterization in patients with HF, in particular-reduced cardiac index. Copeptin could be a useful biomarker for abnormal resting hemodynamics in HF.

U2 - 10.2217/bmm-2017-0439

DO - 10.2217/bmm-2017-0439

M3 - Journal article

C2 - 30058349

VL - 12

SP - 861

EP - 870

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 8

ER -

ID: 221266199