Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion
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Copenhagen Baby Heart Study : a population study of newborns with prenatal inclusion. / Sillesen, Anne-Sophie; Raja, Anna Axelsson; Pihl, Christian; Vøgg, Ruth Ottilia Birgitta; Hedegaard, Morten; Emmersen, Pernille; Sundberg, Karin; Tabor, Ann; Vedel, Cathrine; Zingenberg, Helle; Kruse, Charlotte; Wilken-Jensen, Charlotte; Nielsen, Tina Holm; Jørgensen, Finn Stener; Jeppesen, Dorthe Lisbeth; Søndergaard, Lars; Kamstrup, Pia R; Nordestgaard, Børge G; Frikke-Schmidt, Ruth; Vejlstrup, Niels; Boyd, Heather A; Bundgaard, Henning; Iversen, Kasper.
In: European Journal of Epidemiology, Vol. 34, No. 1, 01.2019, p. 79-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Copenhagen Baby Heart Study
T2 - a population study of newborns with prenatal inclusion
AU - Sillesen, Anne-Sophie
AU - Raja, Anna Axelsson
AU - Pihl, Christian
AU - Vøgg, Ruth Ottilia Birgitta
AU - Hedegaard, Morten
AU - Emmersen, Pernille
AU - Sundberg, Karin
AU - Tabor, Ann
AU - Vedel, Cathrine
AU - Zingenberg, Helle
AU - Kruse, Charlotte
AU - Wilken-Jensen, Charlotte
AU - Nielsen, Tina Holm
AU - Jørgensen, Finn Stener
AU - Jeppesen, Dorthe Lisbeth
AU - Søndergaard, Lars
AU - Kamstrup, Pia R
AU - Nordestgaard, Børge G
AU - Frikke-Schmidt, Ruth
AU - Vejlstrup, Niels
AU - Boyd, Heather A
AU - Bundgaard, Henning
AU - Iversen, Kasper
PY - 2019/1
Y1 - 2019/1
N2 - Congenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and functional cardiac abnormalities. The CBHS will also establish normal values for neonatal cardiac parameters and biomarkers, and study prenatal and early childhood factors potentially affecting later cardiovascular disease risk. The CBHS is an ongoing multicenter, prospective study recruiting from second trimester pregnancy (gestational weeks 18-20) (expected n = 25,000). Information on parents, pregnancy, and delivery are collected. After birth, umbilical cord blood is collected for biochemical analysis, DNA purification, and biobank storage. An echocardiographic examination, electrocardiography, and post-ductal pulse oximetry are performed shortly after birth. Infants diagnosed with significant CHD are referred to a specialist or admitted to hospital, depending on CHD severity. CBHS participants will be followed prospectively as part of specific research projects or regular clinical follow-up for CHD. CBHS design and methodology are described. The CBHS aims to identify new mechanisms underlying cardiovascular disease development and new targets for prevention, early detection, and management of CHD and other cardiac diseases presenting at birth or developing later in life.
AB - Congenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and functional cardiac abnormalities. The CBHS will also establish normal values for neonatal cardiac parameters and biomarkers, and study prenatal and early childhood factors potentially affecting later cardiovascular disease risk. The CBHS is an ongoing multicenter, prospective study recruiting from second trimester pregnancy (gestational weeks 18-20) (expected n = 25,000). Information on parents, pregnancy, and delivery are collected. After birth, umbilical cord blood is collected for biochemical analysis, DNA purification, and biobank storage. An echocardiographic examination, electrocardiography, and post-ductal pulse oximetry are performed shortly after birth. Infants diagnosed with significant CHD are referred to a specialist or admitted to hospital, depending on CHD severity. CBHS participants will be followed prospectively as part of specific research projects or regular clinical follow-up for CHD. CBHS design and methodology are described. The CBHS aims to identify new mechanisms underlying cardiovascular disease development and new targets for prevention, early detection, and management of CHD and other cardiac diseases presenting at birth or developing later in life.
KW - DNA/blood
KW - Denmark/epidemiology
KW - Echocardiography
KW - Electrocardiography
KW - Female
KW - Heart Defects, Congenital/diagnosis
KW - Humans
KW - Infant, Newborn
KW - Male
KW - Pregnancy
KW - Pregnancy Trimester, Second
KW - Prognosis
KW - Prospective Studies
KW - Reference Values
KW - Research Design
KW - Risk Factors
U2 - 10.1007/s10654-018-0448-y
DO - 10.1007/s10654-018-0448-y
M3 - Journal article
C2 - 30306423
VL - 34
SP - 79
EP - 90
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
IS - 1
ER -
ID: 234273795