Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells. / Hemmingsen, Jette Gjerke; Møller, Peter; Jantzen, Kim; Jönsson, Bo A G; Albin, Maria; Wierzbicka, Aneta; Gudmundsson, Anders; Loft, Steffen; Rissler, Jenny.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 775, 28.03.2015, p. 66-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hemmingsen, JG, Møller, P, Jantzen, K, Jönsson, BAG, Albin, M, Wierzbicka, A, Gudmundsson, A, Loft, S & Rissler, J 2015, 'Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 775, pp. 66-71. https://doi.org/10.1016/j.mrfmmm.2015.03.009

APA

Hemmingsen, J. G., Møller, P., Jantzen, K., Jönsson, B. A. G., Albin, M., Wierzbicka, A., Gudmundsson, A., Loft, S., & Rissler, J. (2015). Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 775, 66-71. https://doi.org/10.1016/j.mrfmmm.2015.03.009

Vancouver

Hemmingsen JG, Møller P, Jantzen K, Jönsson BAG, Albin M, Wierzbicka A et al. Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2015 Mar 28;775:66-71. https://doi.org/10.1016/j.mrfmmm.2015.03.009

Author

Hemmingsen, Jette Gjerke ; Møller, Peter ; Jantzen, Kim ; Jönsson, Bo A G ; Albin, Maria ; Wierzbicka, Aneta ; Gudmundsson, Anders ; Loft, Steffen ; Rissler, Jenny. / Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2015 ; Vol. 775. pp. 66-71.

Bibtex

@article{2e7af10da10b43beb964fbdd8298ad99,

title = "Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells",

abstract = "Particulate air pollution increases risk of cancer and cardiopulmonary disease, partly through oxidative stress. Traffic-related noise increases risk of cardiovascular disease and may cause oxidative stress. In this controlled random sequence study, 18 healthy subjects were exposed for 3h to diesel exhaust (DE) at 276μg/m(3) from a passenger car or filtered air, with co-exposure to traffic noise at 48 or 75dB(A). Gene expression markers of inflammation, (interleukin-8 and tumor necrosis factor), oxidative stress (heme oxygenase (decycling-1)) and DNA repair (8-oxoguanine DNA glycosylase (OGG1)) were unaltered in peripheral blood mononuclear cells (PBMCs). No significant differences in DNA damage levels, measured by the comet assay, were observed after DE exposure, whereas exposure to high noise levels was associated with significantly increased levels of hOGG1-sensitive sites in PBMCs. Urinary levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine were unaltered. In auxiliary ex vivo experiments whole blood was incubated with particles from the exposure chamber for 3h without effects on DNA damage in PBMCs or intracellular reactive oxygen species production and expression of CD11b and CD62L adhesion molecules in leukocyte subtypes.CONCLUSION: 3-h exposure to DE caused no genotoxicity, oxidative stress or inflammation in PBMCs, whereas exposure to noise might cause oxidatively damaged DNA.",

author = "Hemmingsen, {Jette Gjerke} and Peter M{\o}ller and Kim Jantzen and J{\"o}nsson, {Bo A G} and Maria Albin and Aneta Wierzbicka and Anders Gudmundsson and Steffen Loft and Jenny Rissler",

year = "2015",

month = mar,

day = "28",

doi = "10.1016/j.mrfmmm.2015.03.009",

language = "English",

volume = "775",

pages = "66--71",

journal = "Mutation Research Letters",

issn = "0027-5107",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Controlled exposure to diesel exhaust and traffic noise - Effects on oxidative stress and activation in mononuclear blood cells

AU - Hemmingsen, Jette Gjerke

AU - Møller, Peter

AU - Jantzen, Kim

AU - Jönsson, Bo A G

AU - Albin, Maria

AU - Wierzbicka, Aneta

AU - Gudmundsson, Anders

AU - Loft, Steffen

AU - Rissler, Jenny

PY - 2015/3/28

Y1 - 2015/3/28

N2 - Particulate air pollution increases risk of cancer and cardiopulmonary disease, partly through oxidative stress. Traffic-related noise increases risk of cardiovascular disease and may cause oxidative stress. In this controlled random sequence study, 18 healthy subjects were exposed for 3h to diesel exhaust (DE) at 276μg/m(3) from a passenger car or filtered air, with co-exposure to traffic noise at 48 or 75dB(A). Gene expression markers of inflammation, (interleukin-8 and tumor necrosis factor), oxidative stress (heme oxygenase (decycling-1)) and DNA repair (8-oxoguanine DNA glycosylase (OGG1)) were unaltered in peripheral blood mononuclear cells (PBMCs). No significant differences in DNA damage levels, measured by the comet assay, were observed after DE exposure, whereas exposure to high noise levels was associated with significantly increased levels of hOGG1-sensitive sites in PBMCs. Urinary levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine were unaltered. In auxiliary ex vivo experiments whole blood was incubated with particles from the exposure chamber for 3h without effects on DNA damage in PBMCs or intracellular reactive oxygen species production and expression of CD11b and CD62L adhesion molecules in leukocyte subtypes.CONCLUSION: 3-h exposure to DE caused no genotoxicity, oxidative stress or inflammation in PBMCs, whereas exposure to noise might cause oxidatively damaged DNA.

AB - Particulate air pollution increases risk of cancer and cardiopulmonary disease, partly through oxidative stress. Traffic-related noise increases risk of cardiovascular disease and may cause oxidative stress. In this controlled random sequence study, 18 healthy subjects were exposed for 3h to diesel exhaust (DE) at 276μg/m(3) from a passenger car or filtered air, with co-exposure to traffic noise at 48 or 75dB(A). Gene expression markers of inflammation, (interleukin-8 and tumor necrosis factor), oxidative stress (heme oxygenase (decycling-1)) and DNA repair (8-oxoguanine DNA glycosylase (OGG1)) were unaltered in peripheral blood mononuclear cells (PBMCs). No significant differences in DNA damage levels, measured by the comet assay, were observed after DE exposure, whereas exposure to high noise levels was associated with significantly increased levels of hOGG1-sensitive sites in PBMCs. Urinary levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine were unaltered. In auxiliary ex vivo experiments whole blood was incubated with particles from the exposure chamber for 3h without effects on DNA damage in PBMCs or intracellular reactive oxygen species production and expression of CD11b and CD62L adhesion molecules in leukocyte subtypes.CONCLUSION: 3-h exposure to DE caused no genotoxicity, oxidative stress or inflammation in PBMCs, whereas exposure to noise might cause oxidatively damaged DNA.

U2 - 10.1016/j.mrfmmm.2015.03.009

DO - 10.1016/j.mrfmmm.2015.03.009

M3 - Journal article

C2 - 25898780

VL - 775

SP - 66

EP - 71

JO - Mutation Research Letters

JF - Mutation Research Letters

SN - 0027-5107

ER -

ID: 135788035