Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men
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Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men. / Jiang, Li; Audouze, Karine; Romero Herrera, Jose Alejandro; Ängquist, Lars Henrik; Kjærulff, Sonny Kim; Izarzugaza, Jose M. G.; Tjønneland, Anne; Halkjær, Jytte; Overvad, Kim; Sørensen, Thorkild I. A.; Brunak, Søren.
In: Clinical Nutrition, Vol. 39, No. 1, 2020, p. 265-275.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men
AU - Jiang, Li
AU - Audouze, Karine
AU - Romero Herrera, Jose Alejandro
AU - Ängquist, Lars Henrik
AU - Kjærulff, Sonny Kim
AU - Izarzugaza, Jose M. G.
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Overvad, Kim
AU - Sørensen, Thorkild I. A.
AU - Brunak, Søren
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Individuals respond differently to dietary intake leading to different associations between diet and traits. Most studies have investigated large cohorts without subgrouping them.OBJECTIVE: The purpose was to identify non-uniform associations between diets and anthropometric traits that appeared to be in conflict with one another across subgroups.DESIGN: We used a cohort comprising 43,790 women and men, the Danish Diet, Cancer and Health study, which includes a baseline examination at age 50-64 years and a follow-up about 5 years later. The baseline examination involved anthropometrics, body fat percentage, a food frequency questionnaire and information on lifestyle. From the questionnaire data we computed association rules between the intake of food groups and changes in waist circumference and body weight. Using association rule mining on subgroups and gender-specific cohorts, we identified non-uniform associations. The two gender-specific cohorts were stratified into subgroups using a non-linear, self-organizing map based method.RESULTS: We found 22 and 7 cases of conflicting rules in 8 participant subgroups for different anthropometric traits in women and men, respectively. For example, in a subgroup of women moderate waist loss was associated with a dietary pattern characterized by low intake in both cabbages and wine, in conflict with the association trends of both dietary factors in the female cohort. The finding of more conflicting rules in women suggests that inter-individual differences in response to dietary intake are stronger in women than in men.CONCLUSIONS: This combined stratification and association discovery approach revealed epidemiological relationships between dietary factors and changes in anthropometric traits in subgroups that take food group interactions into account. Conflicting rules adds an additional layer of complexity that should be integrated into the study of these relationships, for example in relation to genotypes.
AB - BACKGROUND: Individuals respond differently to dietary intake leading to different associations between diet and traits. Most studies have investigated large cohorts without subgrouping them.OBJECTIVE: The purpose was to identify non-uniform associations between diets and anthropometric traits that appeared to be in conflict with one another across subgroups.DESIGN: We used a cohort comprising 43,790 women and men, the Danish Diet, Cancer and Health study, which includes a baseline examination at age 50-64 years and a follow-up about 5 years later. The baseline examination involved anthropometrics, body fat percentage, a food frequency questionnaire and information on lifestyle. From the questionnaire data we computed association rules between the intake of food groups and changes in waist circumference and body weight. Using association rule mining on subgroups and gender-specific cohorts, we identified non-uniform associations. The two gender-specific cohorts were stratified into subgroups using a non-linear, self-organizing map based method.RESULTS: We found 22 and 7 cases of conflicting rules in 8 participant subgroups for different anthropometric traits in women and men, respectively. For example, in a subgroup of women moderate waist loss was associated with a dietary pattern characterized by low intake in both cabbages and wine, in conflict with the association trends of both dietary factors in the female cohort. The finding of more conflicting rules in women suggests that inter-individual differences in response to dietary intake are stronger in women than in men.CONCLUSIONS: This combined stratification and association discovery approach revealed epidemiological relationships between dietary factors and changes in anthropometric traits in subgroups that take food group interactions into account. Conflicting rules adds an additional layer of complexity that should be integrated into the study of these relationships, for example in relation to genotypes.
U2 - 10.1016/j.clnu.2019.02.003
DO - 10.1016/j.clnu.2019.02.003
M3 - Journal article
C2 - 30857909
VL - 39
SP - 265
EP - 275
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 1
ER -
ID: 214826614