Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration

Research output: Contribution to journalJournal articlepeer-review

Standard

Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration. / Garde, Anne Helene; Hansen, Ase Marie; Kristiansen, Jesper; Knudsen, Lisbeth Ehlert; Hansen, Åse Marie.

In: Annals of Occupational Hygiene, Vol. 48, No. 2, 2004, p. 171-9.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Garde, AH, Hansen, AM, Kristiansen, J, Knudsen, LE & Hansen, ÅM 2004, 'Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration', Annals of Occupational Hygiene, vol. 48, no. 2, pp. 171-9.

APA

Garde, A. H., Hansen, A. M., Kristiansen, J., Knudsen, L. E., & Hansen, Å. M. (2004). Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration. Annals of Occupational Hygiene, 48(2), 171-9.

Vancouver

Garde AH, Hansen AM, Kristiansen J, Knudsen LE, Hansen ÅM. Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration. Annals of Occupational Hygiene. 2004;48(2):171-9.

Author

Garde, Anne Helene ; Hansen, Ase Marie ; Kristiansen, Jesper ; Knudsen, Lisbeth Ehlert ; Hansen, Åse Marie. / Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration. In: Annals of Occupational Hygiene. 2004 ; Vol. 48, No. 2. pp. 171-9.

Bibtex

@article{fee1ab9ff5384694bbd16e443931d2d3,
title = "Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration",
abstract = "When measuring biomarkers in urine, volume (and time) or concentration of creatinine are both accepted methods of standardization for diuresis. Both types of standardization contribute uncertainty to the final result. The aim of the present paper was to compare the uncertainty introduced when using the two types of standardization on 24 h samples from healthy individuals. Estimates of uncertainties were based on results from the literature supplemented with data from our own studies. Only the difference in uncertainty related to the two standardization methods was evaluated. It was found that the uncertainty associated with creatinine standardization (19-35%) was higher than the uncertainty related to volume standardization (up to 10%, when not correcting for deviations from 24 h) for 24 h urine samples. However, volume standardization introduced an average bias of 4% due to missed volumes in population studies. When studying a single 24 h sample from one individual, there was a 15-20% risk that the sample was incomplete. In this case a bias of approximately 25% was introduced when using volume standardization, whereas the uncertainty related to creatinine standardization was independent of the completeness of the sample. The uncertainty of creatinine standardization is increased when studying single voids rather than 24 h urine samples. This is partially counteracted by the increased statistical power due to the increased number of samples for each individual. Furthermore, there is a considerable increase in convenience for the participants, when collecting small volumes rather than complete 24 h samples.",
keywords = "Adult, Age Factors, Air Pollutants, Biological Markers, Body Weight, Creatinine, Female, Humans, Male, Middle Aged, Occupational Exposure, Reference Standards, Sensitivity and Specificity, Uncertainty, Urine, Vehicle Emissions",
author = "Garde, {Anne Helene} and Hansen, {Ase Marie} and Jesper Kristiansen and Knudsen, {Lisbeth Ehlert} and Hansen, {{\AA}se Marie}",
year = "2004",
language = "English",
volume = "48",
pages = "171--9",
journal = "Annals of Occupational Hygiene",
issn = "2398-7308",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration

AU - Garde, Anne Helene

AU - Hansen, Ase Marie

AU - Kristiansen, Jesper

AU - Knudsen, Lisbeth Ehlert

AU - Hansen, Åse Marie

PY - 2004

Y1 - 2004

N2 - When measuring biomarkers in urine, volume (and time) or concentration of creatinine are both accepted methods of standardization for diuresis. Both types of standardization contribute uncertainty to the final result. The aim of the present paper was to compare the uncertainty introduced when using the two types of standardization on 24 h samples from healthy individuals. Estimates of uncertainties were based on results from the literature supplemented with data from our own studies. Only the difference in uncertainty related to the two standardization methods was evaluated. It was found that the uncertainty associated with creatinine standardization (19-35%) was higher than the uncertainty related to volume standardization (up to 10%, when not correcting for deviations from 24 h) for 24 h urine samples. However, volume standardization introduced an average bias of 4% due to missed volumes in population studies. When studying a single 24 h sample from one individual, there was a 15-20% risk that the sample was incomplete. In this case a bias of approximately 25% was introduced when using volume standardization, whereas the uncertainty related to creatinine standardization was independent of the completeness of the sample. The uncertainty of creatinine standardization is increased when studying single voids rather than 24 h urine samples. This is partially counteracted by the increased statistical power due to the increased number of samples for each individual. Furthermore, there is a considerable increase in convenience for the participants, when collecting small volumes rather than complete 24 h samples.

AB - When measuring biomarkers in urine, volume (and time) or concentration of creatinine are both accepted methods of standardization for diuresis. Both types of standardization contribute uncertainty to the final result. The aim of the present paper was to compare the uncertainty introduced when using the two types of standardization on 24 h samples from healthy individuals. Estimates of uncertainties were based on results from the literature supplemented with data from our own studies. Only the difference in uncertainty related to the two standardization methods was evaluated. It was found that the uncertainty associated with creatinine standardization (19-35%) was higher than the uncertainty related to volume standardization (up to 10%, when not correcting for deviations from 24 h) for 24 h urine samples. However, volume standardization introduced an average bias of 4% due to missed volumes in population studies. When studying a single 24 h sample from one individual, there was a 15-20% risk that the sample was incomplete. In this case a bias of approximately 25% was introduced when using volume standardization, whereas the uncertainty related to creatinine standardization was independent of the completeness of the sample. The uncertainty of creatinine standardization is increased when studying single voids rather than 24 h urine samples. This is partially counteracted by the increased statistical power due to the increased number of samples for each individual. Furthermore, there is a considerable increase in convenience for the participants, when collecting small volumes rather than complete 24 h samples.

KW - Adult

KW - Age Factors

KW - Air Pollutants

KW - Biological Markers

KW - Body Weight

KW - Creatinine

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Occupational Exposure

KW - Reference Standards

KW - Sensitivity and Specificity

KW - Uncertainty

KW - Urine

KW - Vehicle Emissions

M3 - Journal article

C2 - 14990438

VL - 48

SP - 171

EP - 179

JO - Annals of Occupational Hygiene

JF - Annals of Occupational Hygiene

SN - 2398-7308

IS - 2

ER -

ID: 37474724