Combinatorial solid-phase synthesis of hapalosin mimetics

Research output: Contribution to journal › Journal article › peer-review

Standard

Combinatorial solid-phase synthesis of hapalosin mimetics. / Olsen, Jacob A.; Jensen, Knud J.; Nielsen, John.

In: Journal of Combinatorial Chemistry, Vol. 2, No. 2, 01.03.2000, p. 143-150.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Olsen, JA, Jensen, KJ & Nielsen, J 2000, 'Combinatorial solid-phase synthesis of hapalosin mimetics', Journal of Combinatorial Chemistry, vol. 2, no. 2, pp. 143-150. <http://www.scopus.com/inward/record.url?scp=0034150453&partnerID=8YFLogxK>

APA

Olsen, J. A., Jensen, K. J., & Nielsen, J. (2000). Combinatorial solid-phase synthesis of hapalosin mimetics. Journal of Combinatorial Chemistry, 2(2), 143-150. http://www.scopus.com/inward/record.url?scp=0034150453&partnerID=8YFLogxK

Vancouver

Olsen JA, Jensen KJ, Nielsen J. Combinatorial solid-phase synthesis of hapalosin mimetics. Journal of Combinatorial Chemistry. 2000 Mar 1;2(2):143-150.

Author

Olsen, Jacob A. ; Jensen, Knud J. ; Nielsen, John. / Combinatorial solid-phase synthesis of hapalosin mimetics. In: Journal of Combinatorial Chemistry. 2000 ; Vol. 2, No. 2. pp. 143-150.

Bibtex

@article{b90fe2575b83470dbab68f3bcc345c7a,
title = "Combinatorial solid-phase synthesis of hapalosin mimetics",
abstract = "The solid-phase synthesis of a small library of mimetics of the cyclic depsipeptide hapalosin is described. 3-Amino-4-hydroxy-5-nitrobenzoic acid was anchored through the anilino moiety to a backbone amide linker (BAL) handle support. Using chemoselective reactions and without the need for protecting group manipulations, the benzoic acid group was first amidated, then the aniline nitrogen was acylated, and finally the nitro group was reduced to an amine and acylated or reductively alkylated, to generate a 12-member library.",
author = "Olsen, {Jacob A.} and Jensen, {Knud J.} and John Nielsen",
year = "2000",
month = mar,
day = "1",
language = "English",
volume = "2",
pages = "143--150",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "ACS Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Combinatorial solid-phase synthesis of hapalosin mimetics

AU - Olsen, Jacob A.

AU - Jensen, Knud J.

AU - Nielsen, John

PY - 2000/3/1

Y1 - 2000/3/1

N2 - The solid-phase synthesis of a small library of mimetics of the cyclic depsipeptide hapalosin is described. 3-Amino-4-hydroxy-5-nitrobenzoic acid was anchored through the anilino moiety to a backbone amide linker (BAL) handle support. Using chemoselective reactions and without the need for protecting group manipulations, the benzoic acid group was first amidated, then the aniline nitrogen was acylated, and finally the nitro group was reduced to an amine and acylated or reductively alkylated, to generate a 12-member library.

AB - The solid-phase synthesis of a small library of mimetics of the cyclic depsipeptide hapalosin is described. 3-Amino-4-hydroxy-5-nitrobenzoic acid was anchored through the anilino moiety to a backbone amide linker (BAL) handle support. Using chemoselective reactions and without the need for protecting group manipulations, the benzoic acid group was first amidated, then the aniline nitrogen was acylated, and finally the nitro group was reduced to an amine and acylated or reductively alkylated, to generate a 12-member library.

M3 - Journal article

AN - SCOPUS:0034150453

VL - 2

SP - 143

EP - 150

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

SN - 2156-8952

IS - 2

ER -

ID: 131118506