Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors

Research output: Contribution to journal › Journal article › Research › peer-review

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Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors. / Guo, Xiong; Zhao, Zhiyue; Chen, Dawei; Qiao, Mingxi; Wan, Feng; Cun, Dongmei; Sun, Yi; Yang, Mingshi.

In: Asian Journal of Pharmaceutical Sciences, Vol. 14, No. 1, 2019, p. 78-85.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guo, X, Zhao, Z, Chen, D, Qiao, M, Wan, F, Cun, D, Sun, Y & Yang, M 2019, 'Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors', Asian Journal of Pharmaceutical Sciences, vol. 14, no. 1, pp. 78-85. https://doi.org/10.1016/j.ajps.2018.03.002

APA

Guo, X., Zhao, Z., Chen, D., Qiao, M., Wan, F., Cun, D., Sun, Y., & Yang, M. (2019). Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors. Asian Journal of Pharmaceutical Sciences, 14(1), 78-85. https://doi.org/10.1016/j.ajps.2018.03.002

Vancouver

Guo X, Zhao Z, Chen D, Qiao M, Wan F, Cun D et al. Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors. Asian Journal of Pharmaceutical Sciences. 2019;14(1):78-85. https://doi.org/10.1016/j.ajps.2018.03.002

Author

Guo, Xiong ; Zhao, Zhiyue ; Chen, Dawei ; Qiao, Mingxi ; Wan, Feng ; Cun, Dongmei ; Sun, Yi ; Yang, Mingshi. / Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors. In: Asian Journal of Pharmaceutical Sciences. 2019 ; Vol. 14, No. 1. pp. 78-85.

Bibtex

@article{add2a68312724a83aa3655c1f50cf188,
title = "Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors",
abstract = " Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment. This study was aiming to investigate the potential of concurrent delivery of resveratrol (RES) and docetaxel (DTX) via polymeric nanocarriers to treat breast cancer. To this end, methoxyl poly(ethylene glycol)-poly(D,L-lactide) copolymer (mPEG-PDLA) was prepared and characterized using FTIR and 1 H NMR, and their molecular weights were determined by GPC. Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line (MCF-7 cells). Subsequently, RES and DTX were loaded in the mPEG-PDLA micelles simultaneously, and the morphology, particle size distribution, in vitro release, pharmacokinetic profiles, as well as cytotoxicity to the MCF-7 cells were characterized. IC 50 of RES and DTX in MCF-7 cells were determined to be 23.0 µg/ml and 10.4 µg/ml, respectively, while a lower IC 50 of 4.8 µg/ml of the combination of RES and DTX was obtained. The combination of RES and DTX at a ratio of 1:1 (w/w) generated stronger synergistic effect than other ratios in the MCF-7 cells. RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles, and enhanced cytotoxicity in vitro against MCF-7 cells. The AUC (0→ t ) of DTX and RES in mPEG-PDLA micelles after i.v. administration to rats were 3.0-fold and 1.6-fold higher than that of i.v. injections of the individual drugs. These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors. ",
keywords = "Docetaxel, Drug resistance tumor, Methoxyl poly(ethylene glycol)-poly(D,L-lactide) copolymer (mPEG-PDLA), Micelles, Resveratrol",
author = "Xiong Guo and Zhiyue Zhao and Dawei Chen and Mingxi Qiao and Feng Wan and Dongmei Cun and Yi Sun and Mingshi Yang",
year = "2019",
doi = "10.1016/j.ajps.2018.03.002",
language = "English",
volume = "14",
pages = "78--85",
journal = "Asian Journal of Pharmaceutical Sciences",
issn = "1818-0876",
publisher = "Hong Kong Asiamed Publish House",
number = "1",

}

RIS

TY - JOUR

T1 - Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors

AU - Guo, Xiong

AU - Zhao, Zhiyue

AU - Chen, Dawei

AU - Qiao, Mingxi

AU - Wan, Feng

AU - Cun, Dongmei

AU - Sun, Yi

AU - Yang, Mingshi

PY - 2019

Y1 - 2019

N2 - Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment. This study was aiming to investigate the potential of concurrent delivery of resveratrol (RES) and docetaxel (DTX) via polymeric nanocarriers to treat breast cancer. To this end, methoxyl poly(ethylene glycol)-poly(D,L-lactide) copolymer (mPEG-PDLA) was prepared and characterized using FTIR and 1 H NMR, and their molecular weights were determined by GPC. Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line (MCF-7 cells). Subsequently, RES and DTX were loaded in the mPEG-PDLA micelles simultaneously, and the morphology, particle size distribution, in vitro release, pharmacokinetic profiles, as well as cytotoxicity to the MCF-7 cells were characterized. IC 50 of RES and DTX in MCF-7 cells were determined to be 23.0 µg/ml and 10.4 µg/ml, respectively, while a lower IC 50 of 4.8 µg/ml of the combination of RES and DTX was obtained. The combination of RES and DTX at a ratio of 1:1 (w/w) generated stronger synergistic effect than other ratios in the MCF-7 cells. RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles, and enhanced cytotoxicity in vitro against MCF-7 cells. The AUC (0→ t ) of DTX and RES in mPEG-PDLA micelles after i.v. administration to rats were 3.0-fold and 1.6-fold higher than that of i.v. injections of the individual drugs. These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors.

AB - Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment. This study was aiming to investigate the potential of concurrent delivery of resveratrol (RES) and docetaxel (DTX) via polymeric nanocarriers to treat breast cancer. To this end, methoxyl poly(ethylene glycol)-poly(D,L-lactide) copolymer (mPEG-PDLA) was prepared and characterized using FTIR and 1 H NMR, and their molecular weights were determined by GPC. Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line (MCF-7 cells). Subsequently, RES and DTX were loaded in the mPEG-PDLA micelles simultaneously, and the morphology, particle size distribution, in vitro release, pharmacokinetic profiles, as well as cytotoxicity to the MCF-7 cells were characterized. IC 50 of RES and DTX in MCF-7 cells were determined to be 23.0 µg/ml and 10.4 µg/ml, respectively, while a lower IC 50 of 4.8 µg/ml of the combination of RES and DTX was obtained. The combination of RES and DTX at a ratio of 1:1 (w/w) generated stronger synergistic effect than other ratios in the MCF-7 cells. RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles, and enhanced cytotoxicity in vitro against MCF-7 cells. The AUC (0→ t ) of DTX and RES in mPEG-PDLA micelles after i.v. administration to rats were 3.0-fold and 1.6-fold higher than that of i.v. injections of the individual drugs. These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors.

KW - Docetaxel

KW - Drug resistance tumor

KW - Methoxyl poly(ethylene glycol)-poly(D,L-lactide) copolymer (mPEG-PDLA)

KW - Micelles

KW - Resveratrol

U2 - 10.1016/j.ajps.2018.03.002

DO - 10.1016/j.ajps.2018.03.002

M3 - Journal article

C2 - 32104440

AN - SCOPUS:85045744481

VL - 14

SP - 78

EP - 85

JO - Asian Journal of Pharmaceutical Sciences

JF - Asian Journal of Pharmaceutical Sciences

SN - 1818-0876

IS - 1

ER -

ID: 221825791