Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis
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Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis. / Andersen, Yuki M.F.; Wu, Jashin J.; Thyssen, Jacob P.; Egeberg, Alexander.
In: Journal of the American Academy of Dermatology, Vol. 81, No. 6, 12.2019, p. 1283-1291.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis
AU - Andersen, Yuki M.F.
AU - Wu, Jashin J.
AU - Thyssen, Jacob P.
AU - Egeberg, Alexander
PY - 2019/12
Y1 - 2019/12
N2 - Background: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development. Objective: To investigate the chronology of IMIDs relative to psoriasis. Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230). Results: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients. Limitations: Clinical measurements were unavailable. Conclusion: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.
AB - Background: Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development. Objective: To investigate the chronology of IMIDs relative to psoriasis. Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230). Results: Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients. Limitations: Clinical measurements were unavailable. Conclusion: IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.
KW - autoimmune
KW - comorbidity
KW - epidemiology
KW - HLA-B27
KW - inflammation
KW - psoriasis
KW - psoriatic arthritis
U2 - 10.1016/j.jaad.2019.04.033
DO - 10.1016/j.jaad.2019.04.033
M3 - Journal article
C2 - 31009673
AN - SCOPUS:85071298098
VL - 81
SP - 1283
EP - 1291
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 6
ER -
ID: 241989332