Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen. / Jeppesen, Helene; Sengeløv, Henrik; Eriksson, Frank; Kiilgaard, Jens Folke; Andersen, Susanne Tvede; Lindegaard, Jens; Julian, Hanne Olsen; Heegaard, Steffen.

In: Bone Marrow Transplantation, Vol. 56, 2021, p. 144–154.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jeppesen, H, Sengeløv, H, Eriksson, F, Kiilgaard, JF, Andersen, ST, Lindegaard, J, Julian, HO & Heegaard, S 2021, 'Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen', Bone Marrow Transplantation, vol. 56, pp. 144–154. https://doi.org/10.1038/s41409-020-0993-3

APA

Jeppesen, H., Sengeløv, H., Eriksson, F., Kiilgaard, J. F., Andersen, S. T., Lindegaard, J., Julian, H. O., & Heegaard, S. (2021). Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen. Bone Marrow Transplantation, 56, 144–154. https://doi.org/10.1038/s41409-020-0993-3

Vancouver

Jeppesen H, Sengeløv H, Eriksson F, Kiilgaard JF, Andersen ST, Lindegaard J et al. Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen. Bone Marrow Transplantation. 2021;56:144–154. https://doi.org/10.1038/s41409-020-0993-3

Author

Jeppesen, Helene ; Sengeløv, Henrik ; Eriksson, Frank ; Kiilgaard, Jens Folke ; Andersen, Susanne Tvede ; Lindegaard, Jens ; Julian, Hanne Olsen ; Heegaard, Steffen. / Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen. In: Bone Marrow Transplantation. 2021 ; Vol. 56. pp. 144–154.

Bibtex

@article{bf13b4b0061b4309949336683e3b6062,
title = "Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen",
abstract = "We investigated risks and hazard rates of developing chronic ocular graft-versus-host disease (oGVHD) in a large nationwide, single centre study by using the criteria proposed by “The International Chronic oGVHD Consensus Group”. This retrospective study included 1407 consecutive adults who underwent allogeneic haematopoietic stem cell transplantation (HSCT). Patients were examined by an ophthalmologist according to the hospital{\textquoteright}s guidelines: baseline examination before HSCT, annually up to 5 years after HSCT. The 186 (13%) had dry eye disease before HSCT. The 5-year cumulative incidence of oGVHD was 18% (95% CI: 15–21) after myeloablative (MA) and 35% (95% CI: 30–39) after non-myeloablative conditioning (NMA). Factors associated with the rate of oGVHD were assessed separately according to conditioning regimen by using multiple Cox regression analyses. Factors that increased the rate in the MA group: Malignant disease, Schirmer{\textquoteright}s test≤10 mm/5 min before transplantation, use of female donor, matched unrelated donor, peripheral blood as stem cell source, and grade III-IV acute GVHD. Factors that increased the rate in the NMA group: Schirmer{\textquoteright}s test≤10 mm/5 min before transplantation and higher recipient age. We recommend a baseline ophthalmological examination before HSCT since many of the patients have signs of dry eyes before transplantation which increased the risk and rate of developing oGVHD.",
author = "Helene Jeppesen and Henrik Sengel{\o}v and Frank Eriksson and Kiilgaard, {Jens Folke} and Andersen, {Susanne Tvede} and Jens Lindegaard and Julian, {Hanne Olsen} and Steffen Heegaard",
year = "2021",
doi = "10.1038/s41409-020-0993-3",
language = "English",
volume = "56",
pages = "144–154",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark – factors associated with risks and rates in adults according to conditioning regimen

AU - Jeppesen, Helene

AU - Sengeløv, Henrik

AU - Eriksson, Frank

AU - Kiilgaard, Jens Folke

AU - Andersen, Susanne Tvede

AU - Lindegaard, Jens

AU - Julian, Hanne Olsen

AU - Heegaard, Steffen

PY - 2021

Y1 - 2021

N2 - We investigated risks and hazard rates of developing chronic ocular graft-versus-host disease (oGVHD) in a large nationwide, single centre study by using the criteria proposed by “The International Chronic oGVHD Consensus Group”. This retrospective study included 1407 consecutive adults who underwent allogeneic haematopoietic stem cell transplantation (HSCT). Patients were examined by an ophthalmologist according to the hospital’s guidelines: baseline examination before HSCT, annually up to 5 years after HSCT. The 186 (13%) had dry eye disease before HSCT. The 5-year cumulative incidence of oGVHD was 18% (95% CI: 15–21) after myeloablative (MA) and 35% (95% CI: 30–39) after non-myeloablative conditioning (NMA). Factors associated with the rate of oGVHD were assessed separately according to conditioning regimen by using multiple Cox regression analyses. Factors that increased the rate in the MA group: Malignant disease, Schirmer’s test≤10 mm/5 min before transplantation, use of female donor, matched unrelated donor, peripheral blood as stem cell source, and grade III-IV acute GVHD. Factors that increased the rate in the NMA group: Schirmer’s test≤10 mm/5 min before transplantation and higher recipient age. We recommend a baseline ophthalmological examination before HSCT since many of the patients have signs of dry eyes before transplantation which increased the risk and rate of developing oGVHD.

AB - We investigated risks and hazard rates of developing chronic ocular graft-versus-host disease (oGVHD) in a large nationwide, single centre study by using the criteria proposed by “The International Chronic oGVHD Consensus Group”. This retrospective study included 1407 consecutive adults who underwent allogeneic haematopoietic stem cell transplantation (HSCT). Patients were examined by an ophthalmologist according to the hospital’s guidelines: baseline examination before HSCT, annually up to 5 years after HSCT. The 186 (13%) had dry eye disease before HSCT. The 5-year cumulative incidence of oGVHD was 18% (95% CI: 15–21) after myeloablative (MA) and 35% (95% CI: 30–39) after non-myeloablative conditioning (NMA). Factors associated with the rate of oGVHD were assessed separately according to conditioning regimen by using multiple Cox regression analyses. Factors that increased the rate in the MA group: Malignant disease, Schirmer’s test≤10 mm/5 min before transplantation, use of female donor, matched unrelated donor, peripheral blood as stem cell source, and grade III-IV acute GVHD. Factors that increased the rate in the NMA group: Schirmer’s test≤10 mm/5 min before transplantation and higher recipient age. We recommend a baseline ophthalmological examination before HSCT since many of the patients have signs of dry eyes before transplantation which increased the risk and rate of developing oGVHD.

U2 - 10.1038/s41409-020-0993-3

DO - 10.1038/s41409-020-0993-3

M3 - Journal article

C2 - 32655136

AN - SCOPUS:85087810198

VL - 56

SP - 144

EP - 154

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

ER -

ID: 245077132