Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation

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Chronic inflammation : importance of NOD2 and NALP3 in interleukin-1beta generation. / Ferrero-Miliani, L; Nielsen, O H; Andersen, P S; Girardin, S E.

In: Clinical and Experimental Immunology, Vol. 147, No. 2, 02.2007, p. 227-35.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Ferrero-Miliani, L, Nielsen, OH, Andersen, PS & Girardin, SE 2007, 'Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation', Clinical and Experimental Immunology, vol. 147, no. 2, pp. 227-35. https://doi.org/10.1111/j.1365-2249.2006.03261.x

APA

Ferrero-Miliani, L., Nielsen, O. H., Andersen, P. S., & Girardin, S. E. (2007). Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clinical and Experimental Immunology, 147(2), 227-35. https://doi.org/10.1111/j.1365-2249.2006.03261.x

Vancouver

Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clinical and Experimental Immunology. 2007 Feb;147(2):227-35. https://doi.org/10.1111/j.1365-2249.2006.03261.x

Author

Ferrero-Miliani, L ; Nielsen, O H ; Andersen, P S ; Girardin, S E. / Chronic inflammation : importance of NOD2 and NALP3 in interleukin-1beta generation. In: Clinical and Experimental Immunology. 2007 ; Vol. 147, No. 2. pp. 227-35.

Bibtex

@article{60d83d2157024441a7f686927e00dfd4,
title = "Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation",
abstract = "Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.",
keywords = "Carrier Proteins/immunology, Chronic Disease, Crohn Disease/immunology, Humans, Inflammation/immunology, Interleukin-1beta/biosynthesis, NLR Family, Pyrin Domain-Containing 3 Protein, Nod2 Signaling Adaptor Protein/immunology, Signal Transduction/immunology",
author = "L Ferrero-Miliani and Nielsen, {O H} and Andersen, {P S} and Girardin, {S E}",
year = "2007",
month = "2",
doi = "10.1111/j.1365-2249.2006.03261.x",
language = "English",
volume = "147",
pages = "227--35",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Chronic inflammation

T2 - importance of NOD2 and NALP3 in interleukin-1beta generation

AU - Ferrero-Miliani, L

AU - Nielsen, O H

AU - Andersen, P S

AU - Girardin, S E

PY - 2007/2

Y1 - 2007/2

N2 - Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.

AB - Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.

KW - Carrier Proteins/immunology

KW - Chronic Disease

KW - Crohn Disease/immunology

KW - Humans

KW - Inflammation/immunology

KW - Interleukin-1beta/biosynthesis

KW - NLR Family, Pyrin Domain-Containing 3 Protein

KW - Nod2 Signaling Adaptor Protein/immunology

KW - Signal Transduction/immunology

U2 - 10.1111/j.1365-2249.2006.03261.x

DO - 10.1111/j.1365-2249.2006.03261.x

M3 - Review

C2 - 17223962

VL - 147

SP - 227

EP - 235

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 2

ER -

ID: 222543359