Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples
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Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. / Jiang, Rong; Brummett, Beverly H; Hauser, Elizabeth R; Babyak, Michael A; Siegler, Ilene C; Singh, Abanish; Astrup, Arne; Pedersen, Oluf; Hansen, Torben; Holst, Claus; Sørensen, Thorkild I A; Williams, Redford B.
In: Biological Psychology, Vol. 93, No. 1, 2013, p. 184-189.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples
AU - Jiang, Rong
AU - Brummett, Beverly H
AU - Hauser, Elizabeth R
AU - Babyak, Michael A
AU - Siegler, Ilene C
AU - Singh, Abanish
AU - Astrup, Arne
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Holst, Claus
AU - Sørensen, Thorkild I A
AU - Williams, Redford B
N1 - CURIS 2013 NEXS 055
PY - 2013
Y1 - 2013
N2 - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.
AB - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.
U2 - 10.1016/j.biopsycho.2013.02.006
DO - 10.1016/j.biopsycho.2013.02.006
M3 - Journal article
C2 - 23435269
VL - 93
SP - 184
EP - 189
JO - Biological Psychology
JF - Biological Psychology
SN - 0301-0511
IS - 1
ER -
ID: 44853343