Children with vaccination granulomas and aluminum contact allergy: Evaluation of predispositions, avoidance behavior, and quality of life
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Children with vaccination granulomas and aluminum contact allergy : Evaluation of predispositions, avoidance behavior, and quality of life. / Hoffmann, Stine S.; Thyssen, Jacob P.; Elberling, Jesper; Hansen, Kirsten S.; Johansen, Jeanne D.
In: Contact Dermatitis, Vol. 83, No. 2, 2020, p. 99-107.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Children with vaccination granulomas and aluminum contact allergy
T2 - Evaluation of predispositions, avoidance behavior, and quality of life
AU - Hoffmann, Stine S.
AU - Thyssen, Jacob P.
AU - Elberling, Jesper
AU - Hansen, Kirsten S.
AU - Johansen, Jeanne D.
PY - 2020
Y1 - 2020
N2 - Background: Aluminum contact allergy is mostly seen in children with vaccination granulomas, following immunization with aluminum-adsorbed childhood vaccines. Objectives: To characterize a cohort of children with vaccination granulomas and aluminum allergy concerning early life conditions, exacerbating factors, avoidance behavior, treatments, and potential impact on quality of life. Methods: A questionnaire study was conducted among 177 children aged 0 to 15 years with vaccination granulomas and aluminum allergy, and a reference group of 61 children aged 3 to 14 years with various types of dermatitis undergoing patch testing. Results: All children in the granuloma group were reportedly affected by itch. Infection exacerbated the itch in 59%. Other worsening factors were eating tin-foiled/canned food (31%) and use of aluminum-containing sunscreen (46%). Many parents took precautions to avoid aluminum exposure. Children with granulomas were more likely to be nonadherent to the National Vaccination Program than the reference group (27% vs 2%, P <.001). Parents in the granuloma group reported a decreased life quality for both parents and children compared with the reference group. Conclusions: Itching vaccination granulomas and aluminum allergy have a considerable negative impact on affected children and their families, causing avoidance behavior, reduced adherence to vaccination programs, and a negative effect on the overall life quality.
AB - Background: Aluminum contact allergy is mostly seen in children with vaccination granulomas, following immunization with aluminum-adsorbed childhood vaccines. Objectives: To characterize a cohort of children with vaccination granulomas and aluminum allergy concerning early life conditions, exacerbating factors, avoidance behavior, treatments, and potential impact on quality of life. Methods: A questionnaire study was conducted among 177 children aged 0 to 15 years with vaccination granulomas and aluminum allergy, and a reference group of 61 children aged 3 to 14 years with various types of dermatitis undergoing patch testing. Results: All children in the granuloma group were reportedly affected by itch. Infection exacerbated the itch in 59%. Other worsening factors were eating tin-foiled/canned food (31%) and use of aluminum-containing sunscreen (46%). Many parents took precautions to avoid aluminum exposure. Children with granulomas were more likely to be nonadherent to the National Vaccination Program than the reference group (27% vs 2%, P <.001). Parents in the granuloma group reported a decreased life quality for both parents and children compared with the reference group. Conclusions: Itching vaccination granulomas and aluminum allergy have a considerable negative impact on affected children and their families, causing avoidance behavior, reduced adherence to vaccination programs, and a negative effect on the overall life quality.
KW - allergic contact dermatitis
KW - aluminum
KW - children
KW - contact allergy
KW - granuloma
KW - patch test
KW - quality of life
KW - questionnaire
KW - vaccine
U2 - 10.1111/cod.13538
DO - 10.1111/cod.13538
M3 - Journal article
C2 - 32219858
AN - SCOPUS:85083778924
VL - 83
SP - 99
EP - 107
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 2
ER -
ID: 258403267