Characterization of the hydrodynamics in a miniaturized dissolution apparatus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Characterization of the hydrodynamics in a miniaturized dissolution apparatus. / Johansson, Kristoffer Enøe; Plum, Jakob; Mosleh, Majid; Madsen, Cecilie Maria; Rades, Thomas; Müllertz, Anette.

In: Journal of Pharmaceutical Sciences, Vol. 107, No. 4, 2018, p. 1095-1103.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Johansson, KE, Plum, J, Mosleh, M, Madsen, CM, Rades, T & Müllertz, A 2018, 'Characterization of the hydrodynamics in a miniaturized dissolution apparatus', Journal of Pharmaceutical Sciences, vol. 107, no. 4, pp. 1095-1103. https://doi.org/10.1016/j.xphs.2017.11.022

APA

Johansson, K. E., Plum, J., Mosleh, M., Madsen, C. M., Rades, T., & Müllertz, A. (2018). Characterization of the hydrodynamics in a miniaturized dissolution apparatus. Journal of Pharmaceutical Sciences, 107(4), 1095-1103. https://doi.org/10.1016/j.xphs.2017.11.022

Vancouver

Johansson KE, Plum J, Mosleh M, Madsen CM, Rades T, Müllertz A. Characterization of the hydrodynamics in a miniaturized dissolution apparatus. Journal of Pharmaceutical Sciences. 2018;107(4):1095-1103. https://doi.org/10.1016/j.xphs.2017.11.022

Author

Johansson, Kristoffer Enøe ; Plum, Jakob ; Mosleh, Majid ; Madsen, Cecilie Maria ; Rades, Thomas ; Müllertz, Anette. / Characterization of the hydrodynamics in a miniaturized dissolution apparatus. In: Journal of Pharmaceutical Sciences. 2018 ; Vol. 107, No. 4. pp. 1095-1103.

Bibtex

@article{027f89e6423c4d3d891dc4e5d363d74a,

title = "Characterization of the hydrodynamics in a miniaturized dissolution apparatus",

abstract = "The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics (CFD) simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using three different agitator geometries operated at 50, 100, 150 and 200 RPM as well as different positioning of an UV probe in the vessel was systematically evaluated. The CFD simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.",

keywords = "Journal Article",

author = "Johansson, {Kristoffer En{\o}e} and Jakob Plum and Majid Mosleh and Madsen, {Cecilie Maria} and Thomas Rades and Anette M{\"u}llertz",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",

year = "2018",

doi = "10.1016/j.xphs.2017.11.022",

language = "English",

volume = "107",

pages = "1095--1103",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Characterization of the hydrodynamics in a miniaturized dissolution apparatus

AU - Johansson, Kristoffer Enøe

AU - Plum, Jakob

AU - Mosleh, Majid

AU - Madsen, Cecilie Maria

AU - Rades, Thomas

AU - Müllertz, Anette

PY - 2018

Y1 - 2018

N2 - The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics (CFD) simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using three different agitator geometries operated at 50, 100, 150 and 200 RPM as well as different positioning of an UV probe in the vessel was systematically evaluated. The CFD simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

AB - The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics (CFD) simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using three different agitator geometries operated at 50, 100, 150 and 200 RPM as well as different positioning of an UV probe in the vessel was systematically evaluated. The CFD simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

KW - Journal Article

U2 - 10.1016/j.xphs.2017.11.022

DO - 10.1016/j.xphs.2017.11.022

M3 - Journal article

C2 - 29233728

VL - 107

SP - 1095

EP - 1103

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

ER -

ID: 187586728