Standard
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. / Campiani, G; Morelli, E; Nacci, V; Fattorusso, C; Ramunno, A; Novellino, E; Greenwood, J; Liljefors, T; Griffiths, R; Sinclair, C; Reavy, H; Kristensen, A S; Pickering, D S; Schousboe, A; Cagnotto, A; Fumagalli, E; Mennini, T; Pickering, Darryl.
In:
Journal of Medicinal Chemistry, Vol. 44, No. 26, 2001, p. 4501-4.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Campiani, G, Morelli, E, Nacci, V, Fattorusso, C, Ramunno, A, Novellino, E, Greenwood, J, Liljefors, T, Griffiths, R, Sinclair, C, Reavy, H, Kristensen, AS, Pickering, DS, Schousboe, A, Cagnotto, A, Fumagalli, E, Mennini, T & Pickering, D 2001, 'Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties', Journal of Medicinal Chemistry, vol. 44, no. 26, pp. 4501-4.
APA
Campiani, G., Morelli, E., Nacci, V., Fattorusso, C., Ramunno, A., Novellino, E., Greenwood, J., Liljefors, T., Griffiths, R., Sinclair, C., Reavy, H., Kristensen, A. S., Pickering, D. S., Schousboe, A., Cagnotto, A., Fumagalli, E., Mennini, T., & Pickering, D. (2001). Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. Journal of Medicinal Chemistry, 44(26), 4501-4.
Vancouver
Campiani G, Morelli E, Nacci V, Fattorusso C, Ramunno A, Novellino E et al. Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. Journal of Medicinal Chemistry. 2001;44(26):4501-4.
Author
Campiani, G ; Morelli, E ; Nacci, V ; Fattorusso, C ; Ramunno, A ; Novellino, E ; Greenwood, J ; Liljefors, T ; Griffiths, R ; Sinclair, C ; Reavy, H ; Kristensen, A S ; Pickering, D S ; Schousboe, A ; Cagnotto, A ; Fumagalli, E ; Mennini, T ; Pickering, Darryl. / Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. In: Journal of Medicinal Chemistry. 2001 ; Vol. 44, No. 26. pp. 4501-4.
Bibtex
@article{54c353b06e8f11df928f000ea68e967b,
title = "Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties",
abstract = "(S)-CPW399 (2b) is a novel, potent, and subtype-selective AMPA receptor full agonist that, unlike (S)-willardiine and related compounds, in mouse cerebellar granule cells, stimulated an increase in [Ca(2+)](i), and induced neuronal cell death in a time- and concentration-dependent manner. Compound 2b appears to be a weakly desensitizing, full agonist at AMPA receptors and therefore represents a new pharmacological tool to investigate the role of AMPA receptors in excitotoxicity and their molecular mechanisms of desensitization.",
author = "G Campiani and E Morelli and V Nacci and C Fattorusso and A Ramunno and E Novellino and J Greenwood and T Liljefors and R Griffiths and C Sinclair and H Reavy and Kristensen, {A S} and Pickering, {D S} and A Schousboe and A Cagnotto and E Fumagalli and T Mennini and Darryl Pickering",
note = "Keywords: Alanine; Animals; Brain; Cell Death; Cell Line; Electrophysiology; Excitatory Amino Acid Agonists; Ligands; Mice; Models, Molecular; Neurons; Oocytes; Pyrimidines; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Recombinant Proteins; Stereoisomerism; Xenopus laevis",
year = "2001",
language = "English",
volume = "44",
pages = "4501--4",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "26",
}
RIS
TY - JOUR
T1 - Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties
AU - Campiani, G
AU - Morelli, E
AU - Nacci, V
AU - Fattorusso, C
AU - Ramunno, A
AU - Novellino, E
AU - Greenwood, J
AU - Liljefors, T
AU - Griffiths, R
AU - Sinclair, C
AU - Reavy, H
AU - Kristensen, A S
AU - Pickering, D S
AU - Schousboe, A
AU - Cagnotto, A
AU - Fumagalli, E
AU - Mennini, T
AU - Pickering, Darryl
N1 - Keywords: Alanine; Animals; Brain; Cell Death; Cell Line; Electrophysiology; Excitatory Amino Acid Agonists; Ligands; Mice; Models, Molecular; Neurons; Oocytes; Pyrimidines; Pyrimidinones; Radioligand Assay; Rats; Receptors, AMPA; Recombinant Proteins; Stereoisomerism; Xenopus laevis
PY - 2001
Y1 - 2001
N2 - (S)-CPW399 (2b) is a novel, potent, and subtype-selective AMPA receptor full agonist that, unlike (S)-willardiine and related compounds, in mouse cerebellar granule cells, stimulated an increase in [Ca(2+)](i), and induced neuronal cell death in a time- and concentration-dependent manner. Compound 2b appears to be a weakly desensitizing, full agonist at AMPA receptors and therefore represents a new pharmacological tool to investigate the role of AMPA receptors in excitotoxicity and their molecular mechanisms of desensitization.
AB - (S)-CPW399 (2b) is a novel, potent, and subtype-selective AMPA receptor full agonist that, unlike (S)-willardiine and related compounds, in mouse cerebellar granule cells, stimulated an increase in [Ca(2+)](i), and induced neuronal cell death in a time- and concentration-dependent manner. Compound 2b appears to be a weakly desensitizing, full agonist at AMPA receptors and therefore represents a new pharmacological tool to investigate the role of AMPA receptors in excitotoxicity and their molecular mechanisms of desensitization.
M3 - Journal article
C2 - 11741469
VL - 44
SP - 4501
EP - 4504
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 26
ER -
