Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses. / Goltermann, Lise; Sarusie, Menachem V; Bentin, Thomas.

In: Frontiers in Microbiology, Vol. 6, 1572, 26.01.2016, p. 1-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Goltermann, L, Sarusie, MV & Bentin, T 2016, 'Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses', Frontiers in Microbiology, vol. 6, 1572, pp. 1-5. https://doi.org/10.3389/fmicb.2015.01572

APA

Goltermann, L., Sarusie, M. V., & Bentin, T. (2016). Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses. Frontiers in Microbiology, 6, 1-5. [1572]. https://doi.org/10.3389/fmicb.2015.01572

Vancouver

Goltermann L, Sarusie MV, Bentin T. Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses. Frontiers in Microbiology. 2016 Jan 26;6:1-5. 1572. https://doi.org/10.3389/fmicb.2015.01572

Author

Goltermann, Lise ; Sarusie, Menachem V ; Bentin, Thomas. / Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses. In: Frontiers in Microbiology. 2016 ; Vol. 6. pp. 1-5.

Bibtex

@article{37d471fd56c54913a2da057a95476ba1,
title = "Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses",
abstract = "Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel mechanism for emergence of antibiotic resistance.",
author = "Lise Goltermann and Sarusie, {Menachem V} and Thomas Bentin",
year = "2016",
month = jan,
day = "26",
doi = "10.3389/fmicb.2015.01572",
language = "English",
volume = "6",
pages = "1--5",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses

AU - Goltermann, Lise

AU - Sarusie, Menachem V

AU - Bentin, Thomas

PY - 2016/1/26

Y1 - 2016/1/26

N2 - Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel mechanism for emergence of antibiotic resistance.

AB - Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel mechanism for emergence of antibiotic resistance.

U2 - 10.3389/fmicb.2015.01572

DO - 10.3389/fmicb.2015.01572

M3 - Journal article

C2 - 26858694

VL - 6

SP - 1

EP - 5

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 1572

ER -

ID: 160107832