Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2
Research output: Contribution to journal › Journal article › peer-review
In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-a and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was prospectively analysed in fresh blood, and treatment-associated quantitative and qualitative changes were analysed. By the 4th vaccine, patients showed a marked increase in CD4+ CD25(high) T cell subset from 6% to 22% (P
Original language | English |
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Journal | Scandinavian Journal of Immunology |
Volume | 73 |
Issue number | 3 |
Pages (from-to) | 222-33 |
Number of pages | 12 |
ISSN | 0300-9475 |
DOIs | |
Publication status | Published - 2011 |
ID: 40197021