Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women : A proof-of-concept resting-state functional MRI study. / van Duinkerken, Eelco; Bernardes, Gabriel; van Bloemendaal, Liselotte; Veltman, Dick J.; Barkhof, Frederik; Mograbi, Daniel C.; Gerdes, Victor E. A.; Deacon, Carolyn F.; Holst, Jens J.; Drent, Madeleine L.; Diamant, Michaela; ten Kulve, Jennifer; Ijzerman, Richard G.

In: Diabetes, Obesity and Metabolism, Vol. 23, No. 2, 2021, p. 415-424.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

van Duinkerken, E, Bernardes, G, van Bloemendaal, L, Veltman, DJ, Barkhof, F, Mograbi, DC, Gerdes, VEA, Deacon, CF, Holst, JJ, Drent, ML, Diamant, M, ten Kulve, J & Ijzerman, RG 2021, 'Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study', Diabetes, Obesity and Metabolism, vol. 23, no. 2, pp. 415-424. https://doi.org/10.1111/dom.14233

APA

van Duinkerken, E., Bernardes, G., van Bloemendaal, L., Veltman, D. J., Barkhof, F., Mograbi, D. C., Gerdes, V. E. A., Deacon, C. F., Holst, J. J., Drent, M. L., Diamant, M., ten Kulve, J., & Ijzerman, R. G. (2021). Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study. Diabetes, Obesity and Metabolism, 23(2), 415-424. https://doi.org/10.1111/dom.14233

Vancouver

van Duinkerken E, Bernardes G, van Bloemendaal L, Veltman DJ, Barkhof F, Mograbi DC et al. Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study. Diabetes, Obesity and Metabolism. 2021;23(2):415-424. https://doi.org/10.1111/dom.14233

Author

van Duinkerken, Eelco ; Bernardes, Gabriel ; van Bloemendaal, Liselotte ; Veltman, Dick J. ; Barkhof, Frederik ; Mograbi, Daniel C. ; Gerdes, Victor E. A. ; Deacon, Carolyn F. ; Holst, Jens J. ; Drent, Madeleine L. ; Diamant, Michaela ; ten Kulve, Jennifer ; Ijzerman, Richard G. / Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women : A proof-of-concept resting-state functional MRI study. In: Diabetes, Obesity and Metabolism. 2021 ; Vol. 23, No. 2. pp. 415-424.

Bibtex

@article{60f69a1779e741a5bf0a3c5ead66e256,
title = "Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study",
abstract = "Aim To assess the effects of Roux-en-Y gastric bypass surgery (RYGB)-related changes in glucagon-like peptide-1 (GLP-1) on cerebral resting-state functioning in obese women.Materials and Methods In nine obese females aged 40-54 years in the fasted state, we studied the effects of RYGB and GLP-1 on five a priori selected networks implicated in food- and reward-related processes as well as environment monitoring (default mode, right frontoparietal, basal ganglia, insula/anterior cingulate and anterior cingulate/orbitofrontal networks).Results Before surgery, GLP-1 receptor blockade (using exendin9-39) was associated with increased right caudate nucleus (basal ganglia network) and decreased right middle frontal (right frontoparietal network) connectivity compared with placebo. RYGB resulted in decreased right orbitofrontal (insula/anterior cingulate network) connectivity. In the default mode network, after surgery, GLP-1 receptor blockade had a larger effect on connectivity in this region than GLP-1 receptor blockade before RYGB (all P-FWE <.05). Results remained similar after correction for changes in body weight. Default mode and right frontoparietal network connectivity changes were related to changes in body mass index and food scores after RYGB.Conclusions These findings suggest GLP-1 involvement in resting-state networks related to food and reward processes and monitoring of the internal and external environment, pointing to a potential role for GLP-1-induced changes in resting-state connectivity in RYGB-mediated weight loss and appetite control.",
keywords = "appetite control, bariatric surgery, GLP-1, weight control, BARIATRIC SURGERY, ENDOGENOUS GLP-1, BRAIN CONNECTIVITY, GLUCOSE-TOLERANCE, WEIGHT-LOSS, FOOD, REWARD, ACTIVATION, NETWORKS, FEMALES",
author = "{van Duinkerken}, Eelco and Gabriel Bernardes and {van Bloemendaal}, Liselotte and Veltman, {Dick J.} and Frederik Barkhof and Mograbi, {Daniel C.} and Gerdes, {Victor E. A.} and Deacon, {Carolyn F.} and Holst, {Jens J.} and Drent, {Madeleine L.} and Michaela Diamant and {ten Kulve}, Jennifer and Ijzerman, {Richard G.}",
year = "2021",
doi = "10.1111/dom.14233",
language = "English",
volume = "23",
pages = "415--424",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women

T2 - A proof-of-concept resting-state functional MRI study

AU - van Duinkerken, Eelco

AU - Bernardes, Gabriel

AU - van Bloemendaal, Liselotte

AU - Veltman, Dick J.

AU - Barkhof, Frederik

AU - Mograbi, Daniel C.

AU - Gerdes, Victor E. A.

AU - Deacon, Carolyn F.

AU - Holst, Jens J.

AU - Drent, Madeleine L.

AU - Diamant, Michaela

AU - ten Kulve, Jennifer

AU - Ijzerman, Richard G.

PY - 2021

Y1 - 2021

N2 - Aim To assess the effects of Roux-en-Y gastric bypass surgery (RYGB)-related changes in glucagon-like peptide-1 (GLP-1) on cerebral resting-state functioning in obese women.Materials and Methods In nine obese females aged 40-54 years in the fasted state, we studied the effects of RYGB and GLP-1 on five a priori selected networks implicated in food- and reward-related processes as well as environment monitoring (default mode, right frontoparietal, basal ganglia, insula/anterior cingulate and anterior cingulate/orbitofrontal networks).Results Before surgery, GLP-1 receptor blockade (using exendin9-39) was associated with increased right caudate nucleus (basal ganglia network) and decreased right middle frontal (right frontoparietal network) connectivity compared with placebo. RYGB resulted in decreased right orbitofrontal (insula/anterior cingulate network) connectivity. In the default mode network, after surgery, GLP-1 receptor blockade had a larger effect on connectivity in this region than GLP-1 receptor blockade before RYGB (all P-FWE <.05). Results remained similar after correction for changes in body weight. Default mode and right frontoparietal network connectivity changes were related to changes in body mass index and food scores after RYGB.Conclusions These findings suggest GLP-1 involvement in resting-state networks related to food and reward processes and monitoring of the internal and external environment, pointing to a potential role for GLP-1-induced changes in resting-state connectivity in RYGB-mediated weight loss and appetite control.

AB - Aim To assess the effects of Roux-en-Y gastric bypass surgery (RYGB)-related changes in glucagon-like peptide-1 (GLP-1) on cerebral resting-state functioning in obese women.Materials and Methods In nine obese females aged 40-54 years in the fasted state, we studied the effects of RYGB and GLP-1 on five a priori selected networks implicated in food- and reward-related processes as well as environment monitoring (default mode, right frontoparietal, basal ganglia, insula/anterior cingulate and anterior cingulate/orbitofrontal networks).Results Before surgery, GLP-1 receptor blockade (using exendin9-39) was associated with increased right caudate nucleus (basal ganglia network) and decreased right middle frontal (right frontoparietal network) connectivity compared with placebo. RYGB resulted in decreased right orbitofrontal (insula/anterior cingulate network) connectivity. In the default mode network, after surgery, GLP-1 receptor blockade had a larger effect on connectivity in this region than GLP-1 receptor blockade before RYGB (all P-FWE <.05). Results remained similar after correction for changes in body weight. Default mode and right frontoparietal network connectivity changes were related to changes in body mass index and food scores after RYGB.Conclusions These findings suggest GLP-1 involvement in resting-state networks related to food and reward processes and monitoring of the internal and external environment, pointing to a potential role for GLP-1-induced changes in resting-state connectivity in RYGB-mediated weight loss and appetite control.

KW - appetite control

KW - bariatric surgery

KW - GLP-1

KW - weight control

KW - BARIATRIC SURGERY

KW - ENDOGENOUS GLP-1

KW - BRAIN CONNECTIVITY

KW - GLUCOSE-TOLERANCE

KW - WEIGHT-LOSS

KW - FOOD

KW - REWARD

KW - ACTIVATION

KW - NETWORKS

KW - FEMALES

U2 - 10.1111/dom.14233

DO - 10.1111/dom.14233

M3 - Journal article

C2 - 33084088

VL - 23

SP - 415

EP - 424

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 2

ER -

ID: 251578383