Central 5-HT Neurotransmission Modulates Weight Loss following Gastric Bypass Surgery in Obese Individuals
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Central 5-HT Neurotransmission Modulates Weight Loss following Gastric Bypass Surgery in Obese Individuals. / Haahr, M. E.; Hansen, D. L.; Fisher, P. M.; Svarer, C.; Stenbæk, D. S.; Madsen, K.; Madsen, J.; Holst, J. J.; Baaré, W. F. C.; Hojgaard, L.; Almdal, T.; Knudsen, G. M.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, No. 14, 08.04.2015, p. 5884-5889.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Central 5-HT Neurotransmission Modulates Weight Loss following Gastric Bypass Surgery in Obese Individuals
AU - Haahr, M. E.
AU - Hansen, D. L.
AU - Fisher, P. M.
AU - Svarer, C.
AU - Stenbæk, D. S.
AU - Madsen, K.
AU - Madsen, J.
AU - Holst, J. J.
AU - Baaré, W. F. C.
AU - Hojgaard, L.
AU - Almdal, T.
AU - Knudsen, G. M.
N1 - Copyright © 2015 the authors 0270-6474/15/355884-06$15.00/0.
PY - 2015/4/8
Y1 - 2015/4/8
N2 - The cerebral serotonin (5-HT) system shows distinct differences in obesity compared with the lean state. Here, it was investigated whether serotonergic neurotransmission in obesity is a stable trait or changes in association with weight loss induced by Roux-in-Y gastric bypass (RYGB) surgery. In vivo cerebral 5-HT2A receptor and 5-HT transporter binding was determined by positron emission tomography in 21 obese [four men; body mass index (BMI), 40.1 ± 4.1 kg/m(2)] and 10 lean (three men; BMI, 24.6 ± 1.5 kg/m(2)) individuals. Fourteen obese individuals were re-examined after RYGB surgery. First, it was confirmed that obese individuals have higher cerebral 5-HT2A receptor binding than lean individuals. Importantly, we found that higher presurgical 5-HT2A receptor binding predicted greater weight loss after RYGB and that the change in 5-HT2A receptor and 5-HT transporter binding correlated with weight loss after RYGB. The changes in the 5-HT neurotransmission before and after RYGB are in accordance with a model wherein the cerebral extracellular 5-HT level modulates the regulation of body weight. Our findings support that the cerebral 5-HT system contributes both to establish the obese condition and to regulate the body weight in response to RYGB.
AB - The cerebral serotonin (5-HT) system shows distinct differences in obesity compared with the lean state. Here, it was investigated whether serotonergic neurotransmission in obesity is a stable trait or changes in association with weight loss induced by Roux-in-Y gastric bypass (RYGB) surgery. In vivo cerebral 5-HT2A receptor and 5-HT transporter binding was determined by positron emission tomography in 21 obese [four men; body mass index (BMI), 40.1 ± 4.1 kg/m(2)] and 10 lean (three men; BMI, 24.6 ± 1.5 kg/m(2)) individuals. Fourteen obese individuals were re-examined after RYGB surgery. First, it was confirmed that obese individuals have higher cerebral 5-HT2A receptor binding than lean individuals. Importantly, we found that higher presurgical 5-HT2A receptor binding predicted greater weight loss after RYGB and that the change in 5-HT2A receptor and 5-HT transporter binding correlated with weight loss after RYGB. The changes in the 5-HT neurotransmission before and after RYGB are in accordance with a model wherein the cerebral extracellular 5-HT level modulates the regulation of body weight. Our findings support that the cerebral 5-HT system contributes both to establish the obese condition and to regulate the body weight in response to RYGB.
U2 - 10.1523/JNEUROSCI.3348-14.2015
DO - 10.1523/JNEUROSCI.3348-14.2015
M3 - Journal article
C2 - 25855196
VL - 35
SP - 5884
EP - 5889
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
SN - 0270-6474
IS - 14
ER -
ID: 137418869