Cause-specific mortality in adults with atopic dermatitis
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Cause-specific mortality in adults with atopic dermatitis. / Thyssen, Jacob P; Skov, Lone; Egeberg, Alexander.
In: Journal of the American Academy of Dermatology, Vol. 78, No. 3, 2018, p. 506-510.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cause-specific mortality in adults with atopic dermatitis
AU - Thyssen, Jacob P
AU - Skov, Lone
AU - Egeberg, Alexander
N1 - Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Adult atopic dermatitis (AD) has been associated with several comorbidities, but cause-specific mortality risk is unknown.OBJECTIVE: To examine cause-specific death rates and risk in adults with AD.METHODS: We performed cross-linkage of nationwide health care and cause of death registers. Adult patients with AD were matched with 10 controls per study subject. We calculated incidence rates per 1000 person-years and hazard ratios (HRs) of cause-specific death with 95% confidence intervals (95% CIs) using Cox proportional hazards models.RESULTS: A total of 8686 patients and 86,860 matched controls were studied. The risk for death due to any cause was significantly increased in patients with AD (HR 1.27, 95%CI 1.11-1.45). Significant causes included cardiovascular (HR 1.45; 95% CI 1.07-1.96), infectious (HR 3.71; 95% CI 1.43-9.60), and urogenital diseases (HR 5.51; 95% CI 1.54-19.80). No increased risk for death due to cancer, endocrine, neurologic, psychiatric, respiratory, or gastroenterologic disease was observed.LIMITATIONS: The results might not be generalizable to patients seen exclusively by primary care physicians.CONCLUSION: Adults with atopic dermatitis had slightly increased risk for death during follow-up. While the risk for death from cardiovascular, urogenital, and infectious diseases was slightly elevated among patients with AD, the absolute risk was very low.
AB - BACKGROUND: Adult atopic dermatitis (AD) has been associated with several comorbidities, but cause-specific mortality risk is unknown.OBJECTIVE: To examine cause-specific death rates and risk in adults with AD.METHODS: We performed cross-linkage of nationwide health care and cause of death registers. Adult patients with AD were matched with 10 controls per study subject. We calculated incidence rates per 1000 person-years and hazard ratios (HRs) of cause-specific death with 95% confidence intervals (95% CIs) using Cox proportional hazards models.RESULTS: A total of 8686 patients and 86,860 matched controls were studied. The risk for death due to any cause was significantly increased in patients with AD (HR 1.27, 95%CI 1.11-1.45). Significant causes included cardiovascular (HR 1.45; 95% CI 1.07-1.96), infectious (HR 3.71; 95% CI 1.43-9.60), and urogenital diseases (HR 5.51; 95% CI 1.54-19.80). No increased risk for death due to cancer, endocrine, neurologic, psychiatric, respiratory, or gastroenterologic disease was observed.LIMITATIONS: The results might not be generalizable to patients seen exclusively by primary care physicians.CONCLUSION: Adults with atopic dermatitis had slightly increased risk for death during follow-up. While the risk for death from cardiovascular, urogenital, and infectious diseases was slightly elevated among patients with AD, the absolute risk was very low.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cardiovascular Diseases/mortality
KW - Case-Control Studies
KW - Cause of Death
KW - Denmark/epidemiology
KW - Dermatitis, Atopic/mortality
KW - Female
KW - Female Urogenital Diseases/mortality
KW - Humans
KW - Infection/mortality
KW - Male
KW - Male Urogenital Diseases/mortality
KW - Middle Aged
KW - Proportional Hazards Models
KW - Registries
U2 - 10.1016/j.jaad.2017.10.032
DO - 10.1016/j.jaad.2017.10.032
M3 - Journal article
C2 - 29102489
VL - 78
SP - 506
EP - 510
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 3
ER -
ID: 216463220