Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects

Research output: Contribution to journal › Journal article › Research › peer-review

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Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects. / Karottki, Dorina Gabriela; Bekö, Gabriel; Clausen, Geo; Madsen, Anne Mette; Andersen, Zorana Jovanovic; Massling, Andreas; Ketzel, Matthias; Ellermann, Thomas; Lund, Rikke; Sigsgaard, Torben; Møller, Peter; Loft, Steffen.

In: Environment International, Vol. 73, 12.2014, p. 372-381.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Karottki, DG, Bekö, G, Clausen, G, Madsen, AM, Andersen, ZJ, Massling, A, Ketzel, M, Ellermann, T, Lund, R, Sigsgaard, T, Møller, P & Loft, S 2014, 'Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects', Environment International, vol. 73, pp. 372-381. https://doi.org/10.1016/j.envint.2014.08.019

APA

Karottki, D. G., Bekö, G., Clausen, G., Madsen, A. M., Andersen, Z. J., Massling, A., Ketzel, M., Ellermann, T., Lund, R., Sigsgaard, T., Møller, P., & Loft, S. (2014). Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects. Environment International, 73, 372-381. https://doi.org/10.1016/j.envint.2014.08.019

Vancouver

Karottki DG, Bekö G, Clausen G, Madsen AM, Andersen ZJ, Massling A et al. Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects. Environment International. 2014 Dec;73:372-381. https://doi.org/10.1016/j.envint.2014.08.019

Author

Karottki, Dorina Gabriela ; Bekö, Gabriel ; Clausen, Geo ; Madsen, Anne Mette ; Andersen, Zorana Jovanovic ; Massling, Andreas ; Ketzel, Matthias ; Ellermann, Thomas ; Lund, Rikke ; Sigsgaard, Torben ; Møller, Peter ; Loft, Steffen. / Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects. In: Environment International. 2014 ; Vol. 73. pp. 372-381.

Bibtex

@article{d7a579ac50b7436a9d894fcc2c3ce34a,

title = "Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects",

abstract = "This cross-sectional study investigated the relationship between exposure to airborne indoor and outdoor particulate matter (PM) and cardiovascular and respiratory health in a population-based sample of 58 residences in Copenhagen, Denmark. Over a 2-day period indoor particle number concentrations (PNC, 10-300nm) and PM2.5 (aerodynamic diameter<2.5μm) were monitored for each of the residences in the living room, and outdoor PNC (10-280nm), PM2.5 and PM10 (aerodynamic diameter<10μm) were monitored at an urban background station in Copenhagen. In the morning, after the 2-day monitoring period, we measured microvascular function (MVF) and lung function and collected blood samples for biomarkers related to inflammation, in 78 middle-aged residents. Bacteria, endotoxin and fungi were analyzed in material from electrostatic dust fall collectors placed in the residences for 4weeks. Data were analyzed using linear regression with the generalized estimating equation approach. Statistically significant associations were found between indoor PNC, dominated by indoor use of candles, and lower lung function, the prediabetic marker HbA1c and systemic inflammatory markers observed as changes in leukocyte differential count and expression of adhesion markers on monocytes, whereas C-reactive protein was significantly associated with indoor PM2.5. The presence of indoor endotoxin was associated with lower lung function and expression of adhesion markers on monocytes. An inverse association between outdoor PNC and MVF was also statistically significant. The study suggests that PNC in the outdoor environment may be associated with decreased MVF, while PNC, mainly driven by candle burning, and bioaerosols in the indoor environment may have a negative effect on lung function and markers of systemic inflammation and diabetes.",

author = "Karottki, {Dorina Gabriela} and Gabriel Bek{\"o} and Geo Clausen and Madsen, {Anne Mette} and Andersen, {Zorana Jovanovic} and Andreas Massling and Matthias Ketzel and Thomas Ellermann and Rikke Lund and Torben Sigsgaard and Peter M{\o}ller and Steffen Loft",

year = "2014",

month = dec,

doi = "10.1016/j.envint.2014.08.019",

language = "English",

volume = "73",

pages = "372--381",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Cardiovascular and lung function in relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle-aged subjects

AU - Karottki, Dorina Gabriela

AU - Bekö, Gabriel

AU - Clausen, Geo

AU - Madsen, Anne Mette

AU - Andersen, Zorana Jovanovic

AU - Massling, Andreas

AU - Ketzel, Matthias

AU - Ellermann, Thomas

AU - Lund, Rikke

AU - Sigsgaard, Torben

AU - Møller, Peter

AU - Loft, Steffen

PY - 2014/12

Y1 - 2014/12

N2 - This cross-sectional study investigated the relationship between exposure to airborne indoor and outdoor particulate matter (PM) and cardiovascular and respiratory health in a population-based sample of 58 residences in Copenhagen, Denmark. Over a 2-day period indoor particle number concentrations (PNC, 10-300nm) and PM2.5 (aerodynamic diameter<2.5μm) were monitored for each of the residences in the living room, and outdoor PNC (10-280nm), PM2.5 and PM10 (aerodynamic diameter<10μm) were monitored at an urban background station in Copenhagen. In the morning, after the 2-day monitoring period, we measured microvascular function (MVF) and lung function and collected blood samples for biomarkers related to inflammation, in 78 middle-aged residents. Bacteria, endotoxin and fungi were analyzed in material from electrostatic dust fall collectors placed in the residences for 4weeks. Data were analyzed using linear regression with the generalized estimating equation approach. Statistically significant associations were found between indoor PNC, dominated by indoor use of candles, and lower lung function, the prediabetic marker HbA1c and systemic inflammatory markers observed as changes in leukocyte differential count and expression of adhesion markers on monocytes, whereas C-reactive protein was significantly associated with indoor PM2.5. The presence of indoor endotoxin was associated with lower lung function and expression of adhesion markers on monocytes. An inverse association between outdoor PNC and MVF was also statistically significant. The study suggests that PNC in the outdoor environment may be associated with decreased MVF, while PNC, mainly driven by candle burning, and bioaerosols in the indoor environment may have a negative effect on lung function and markers of systemic inflammation and diabetes.

AB - This cross-sectional study investigated the relationship between exposure to airborne indoor and outdoor particulate matter (PM) and cardiovascular and respiratory health in a population-based sample of 58 residences in Copenhagen, Denmark. Over a 2-day period indoor particle number concentrations (PNC, 10-300nm) and PM2.5 (aerodynamic diameter<2.5μm) were monitored for each of the residences in the living room, and outdoor PNC (10-280nm), PM2.5 and PM10 (aerodynamic diameter<10μm) were monitored at an urban background station in Copenhagen. In the morning, after the 2-day monitoring period, we measured microvascular function (MVF) and lung function and collected blood samples for biomarkers related to inflammation, in 78 middle-aged residents. Bacteria, endotoxin and fungi were analyzed in material from electrostatic dust fall collectors placed in the residences for 4weeks. Data were analyzed using linear regression with the generalized estimating equation approach. Statistically significant associations were found between indoor PNC, dominated by indoor use of candles, and lower lung function, the prediabetic marker HbA1c and systemic inflammatory markers observed as changes in leukocyte differential count and expression of adhesion markers on monocytes, whereas C-reactive protein was significantly associated with indoor PM2.5. The presence of indoor endotoxin was associated with lower lung function and expression of adhesion markers on monocytes. An inverse association between outdoor PNC and MVF was also statistically significant. The study suggests that PNC in the outdoor environment may be associated with decreased MVF, while PNC, mainly driven by candle burning, and bioaerosols in the indoor environment may have a negative effect on lung function and markers of systemic inflammation and diabetes.

U2 - 10.1016/j.envint.2014.08.019

DO - 10.1016/j.envint.2014.08.019

M3 - Journal article

C2 - 25233101

VL - 73

SP - 372

EP - 381

JO - Environment international

JF - Environment international

SN - 0160-4120

ER -

ID: 124841001