Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

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  • Cancer...

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  • Stefan Enroth
  • Alvaro Rada-Iglesisas
  • Andersson, Robin
  • Ola Wallerman
  • Alkwin Wanders
  • Lars Påhlman
  • Jan Komorowski
  • Claes Wadelius
Despite their well-established functional roles, histone modifications have received less attention than DNA methylation in the cancer field. In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples.
Original languageEnglish
Article number450
JournalB M C Cancer
Number of pages13
Publication statusPublished - 2011

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