C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response
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C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response. / Schiøtz, P O; Høiby, N; Morling, N; Sørensen, H.
In: Human Heredity, Vol. 28, No. 4, 1978, p. 293-300.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response
AU - Schiøtz, P O
AU - Høiby, N
AU - Morling, N
AU - Sørensen, H
N1 - Keywords: Adolescent; Adult; Antibodies, Bacterial; Child; Child, Preschool; Complement C3; Cystic Fibrosis; Denmark; Female; Gene Frequency; Humans; Infant; Infant, Newborn; Male; Phenotype; Polymorphism, Genetic; Pseudomonas Infections
PY - 1978
Y1 - 1978
N2 - The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.
AB - The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.
M3 - Journal article
C2 - 658974
VL - 28
SP - 293
EP - 300
JO - Human Heredity
JF - Human Heredity
SN - 0001-5652
IS - 4
ER -
ID: 18693778