Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. / Yu, Haidong; Dilbaz, Sedat; Coßmann, Jonas; Hoang, Anh Cuong; Diedrich, Victoria; Herwig, Annika; Harauma, Akiko; Hoshi, Yukino; Moriguchi, Toru; Landgraf, Kathrin; Körner, Antje; Lucas, Christina; Brodesser, Susanne; Balogh, Lajos; Thuróczy, Julianna; Karemore, Gopal; Kuefner, Michael Scott; Park, Edwards A; Rapp, Christine; Travers, Jeffrey Bryant; Röszer, Tamás.

In: The Journal of Clinical Investigation, Vol. 129, No. 6, 2019, p. 2485-2499.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yu, H, Dilbaz, S, Coßmann, J, Hoang, AC, Diedrich, V, Herwig, A, Harauma, A, Hoshi, Y, Moriguchi, T, Landgraf, K, Körner, A, Lucas, C, Brodesser, S, Balogh, L, Thuróczy, J, Karemore, G, Kuefner, MS, Park, EA, Rapp, C, Travers, JB & Röszer, T 2019, 'Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages', The Journal of Clinical Investigation, vol. 129, no. 6, pp. 2485-2499. https://doi.org/10.1172/JCI125646

APA

Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., Körner, A., Lucas, C., Brodesser, S., Balogh, L., Thuróczy, J., Karemore, G., Kuefner, M. S., Park, E. A., Rapp, C., ... Röszer, T. (2019). Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. The Journal of Clinical Investigation, 129(6), 2485-2499. https://doi.org/10.1172/JCI125646

Vancouver

Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A et al. Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. The Journal of Clinical Investigation. 2019;129(6):2485-2499. https://doi.org/10.1172/JCI125646

Author

Yu, Haidong ; Dilbaz, Sedat ; Coßmann, Jonas ; Hoang, Anh Cuong ; Diedrich, Victoria ; Herwig, Annika ; Harauma, Akiko ; Hoshi, Yukino ; Moriguchi, Toru ; Landgraf, Kathrin ; Körner, Antje ; Lucas, Christina ; Brodesser, Susanne ; Balogh, Lajos ; Thuróczy, Julianna ; Karemore, Gopal ; Kuefner, Michael Scott ; Park, Edwards A ; Rapp, Christine ; Travers, Jeffrey Bryant ; Röszer, Tamás. / Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. In: The Journal of Clinical Investigation. 2019 ; Vol. 129, No. 6. pp. 2485-2499.

Bibtex

@article{7c12b3bf0821438e94372a6acdd2c1dd,
title = "Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages",
abstract = "Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.",
author = "Haidong Yu and Sedat Dilbaz and Jonas Co{\ss}mann and Hoang, {Anh Cuong} and Victoria Diedrich and Annika Herwig and Akiko Harauma and Yukino Hoshi and Toru Moriguchi and Kathrin Landgraf and Antje K{\"o}rner and Christina Lucas and Susanne Brodesser and Lajos Balogh and Julianna Thur{\'o}czy and Gopal Karemore and Kuefner, {Michael Scott} and Park, {Edwards A} and Christine Rapp and Travers, {Jeffrey Bryant} and Tam{\'a}s R{\"o}szer",
year = "2019",
doi = "10.1172/JCI125646",
language = "English",
volume = "129",
pages = "2485--2499",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "6",

}

RIS

TY - JOUR

T1 - Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

AU - Yu, Haidong

AU - Dilbaz, Sedat

AU - Coßmann, Jonas

AU - Hoang, Anh Cuong

AU - Diedrich, Victoria

AU - Herwig, Annika

AU - Harauma, Akiko

AU - Hoshi, Yukino

AU - Moriguchi, Toru

AU - Landgraf, Kathrin

AU - Körner, Antje

AU - Lucas, Christina

AU - Brodesser, Susanne

AU - Balogh, Lajos

AU - Thuróczy, Julianna

AU - Karemore, Gopal

AU - Kuefner, Michael Scott

AU - Park, Edwards A

AU - Rapp, Christine

AU - Travers, Jeffrey Bryant

AU - Röszer, Tamás

PY - 2019

Y1 - 2019

N2 - Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.

AB - Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.

U2 - 10.1172/JCI125646

DO - 10.1172/JCI125646

M3 - Journal article

C2 - 31081799

VL - 129

SP - 2485

EP - 2499

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 6

ER -

ID: 219535038