Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction

Research output: Contribution to journalJournal articleResearchpeer-review

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Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction. / Frydland, Martin; Moller, Jacob E.; Lindholm, Matias G.; Hansen, Rikke; Wiberg, Sebastian; Helgestad, Ole Kristian Lerche; Thomsen, Jakob H.; Goetze, Jens P.; Engstrom, Thomas; Frikke-Schmidt, Ruth; Ravn, Hanne B.; Holmvang, Lene; Jensen, Lisette O.; Kjaergaard, Jesper; Hassager, Christian.

In: European Heart Journal: Acute Cardiovascular Care, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Frydland, M, Moller, JE, Lindholm, MG, Hansen, R, Wiberg, S, Helgestad, OKL, Thomsen, JH, Goetze, JP, Engstrom, T, Frikke-Schmidt, R, Ravn, HB, Holmvang, L, Jensen, LO, Kjaergaard, J & Hassager, C 2020, 'Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction', European Heart Journal: Acute Cardiovascular Care. https://doi.org/10.1177/2048872619896063

APA

Frydland, M., Moller, J. E., Lindholm, M. G., Hansen, R., Wiberg, S., Helgestad, O. K. L., ... Hassager, C. (2020). Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care, [2048872619896063]. https://doi.org/10.1177/2048872619896063

Vancouver

Frydland M, Moller JE, Lindholm MG, Hansen R, Wiberg S, Helgestad OKL et al. Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care. 2020. 2048872619896063. https://doi.org/10.1177/2048872619896063

Author

Frydland, Martin ; Moller, Jacob E. ; Lindholm, Matias G. ; Hansen, Rikke ; Wiberg, Sebastian ; Helgestad, Ole Kristian Lerche ; Thomsen, Jakob H. ; Goetze, Jens P. ; Engstrom, Thomas ; Frikke-Schmidt, Ruth ; Ravn, Hanne B. ; Holmvang, Lene ; Jensen, Lisette O. ; Kjaergaard, Jesper ; Hassager, Christian. / Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction. In: European Heart Journal: Acute Cardiovascular Care. 2020.

Bibtex

@article{3d94576a00de4d1d9e1fbd8a0f402440,
title = "Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction",
abstract = "Background: Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown. Methods and results: In 93{\%} of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10{\%}) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9{\%}). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19-3.13) even when adjusted for the recently developed Observatoire Regional Breton sur l'Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Regional Breton sur l'Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006). Conclusions: Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.",
keywords = "ST-elevation myocardial infarction, cardiogenic shock, inflammation, neuroendocrine response, biomarkers",
author = "Martin Frydland and Moller, {Jacob E.} and Lindholm, {Matias G.} and Rikke Hansen and Sebastian Wiberg and Helgestad, {Ole Kristian Lerche} and Thomsen, {Jakob H.} and Goetze, {Jens P.} and Thomas Engstrom and Ruth Frikke-Schmidt and Ravn, {Hanne B.} and Lene Holmvang and Jensen, {Lisette O.} and Jesper Kjaergaard and Christian Hassager",
year = "2020",
doi = "10.1177/2048872619896063",
language = "English",
journal = "European Heart Journal: Acute Cardiovascular Care",
issn = "2048-8726",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction

AU - Frydland, Martin

AU - Moller, Jacob E.

AU - Lindholm, Matias G.

AU - Hansen, Rikke

AU - Wiberg, Sebastian

AU - Helgestad, Ole Kristian Lerche

AU - Thomsen, Jakob H.

AU - Goetze, Jens P.

AU - Engstrom, Thomas

AU - Frikke-Schmidt, Ruth

AU - Ravn, Hanne B.

AU - Holmvang, Lene

AU - Jensen, Lisette O.

AU - Kjaergaard, Jesper

AU - Hassager, Christian

PY - 2020

Y1 - 2020

N2 - Background: Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown. Methods and results: In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19-3.13) even when adjusted for the recently developed Observatoire Regional Breton sur l'Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Regional Breton sur l'Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006). Conclusions: Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.

AB - Background: Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown. Methods and results: In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19-3.13) even when adjusted for the recently developed Observatoire Regional Breton sur l'Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Regional Breton sur l'Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006). Conclusions: Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.

KW - ST-elevation myocardial infarction

KW - cardiogenic shock

KW - inflammation

KW - neuroendocrine response

KW - biomarkers

U2 - 10.1177/2048872619896063

DO - 10.1177/2048872619896063

M3 - Journal article

C2 - 31961195

JO - European Heart Journal: Acute Cardiovascular Care

JF - European Heart Journal: Acute Cardiovascular Care

SN - 2048-8726

M1 - 2048872619896063

ER -

ID: 237105148