Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans
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Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.
Original language | English |
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Article number | 103791 |
Journal | iScience |
Volume | 25 |
Issue number | 2 |
Number of pages | 18 |
ISSN | 2589-0042 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
© 2022 The Author(s)
- Biological sciences, Developmental neuroscience, Molecular neuroscience
Research areas
ID: 345417875